What is the cause of a swollen inguinal (groin area) lymph node?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 23, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Swollen Inguinal Lymph Node

  • Single Most Likely Diagnosis
    • Inguinal lymphadenitis due to bacterial or viral infection: This is the most common cause of swollen inguinal lymph nodes, often resulting from infections in the lower extremities, genital area, or anal region.
  • Other Likely Diagnoses
    • Sexually Transmitted Infections (STIs) such as chlamydia, gonorrhea, or syphilis: These infections can cause lymphadenopathy, particularly in the inguinal region, and are common in sexually active individuals.
    • Dermatological conditions like eczema, psoriasis, or fungal infections: Skin conditions in the lower extremities or genital area can lead to inguinal lymphadenopathy due to the body's immune response.
    • Reactive lymphadenitis due to local trauma or surgery: Recent trauma or surgical procedures in the areas drained by the inguinal lymph nodes can cause reactive lymphadenitis.
  • Do Not Miss Diagnoses
    • Lymphoma: Although less common, lymphoma can present with lymphadenopathy, including in the inguinal region, and is critical to diagnose early for effective treatment.
    • Metastatic cancer: Cancers from the lower extremities, genital area, or anal region can metastasize to the inguinal lymph nodes, making early detection crucial for prognosis.
    • Tuberculosis or other systemic infections: Though less common in some regions, tuberculosis and other systemic infections can cause lymphadenopathy and have significant implications for public health and individual treatment.
  • Rare Diagnoses
    • Cat-scratch disease: Caused by Bartonella henselae, this infection can lead to lymphadenopathy, typically after a cat scratch, and is more common in children.
    • Toxoplasmosis: A parasitic infection that can cause lymphadenopathy, though it is less commonly associated with inguinal lymph nodes specifically.
    • Kikuchi-Fujimoto disease: A rare, self-limiting condition that can cause lymphadenopathy, often in the cervical region but potentially in other areas, including the inguinal region.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.