From the Research
Amoxicillin-clavulanate is not typically administered intravenously, but when administered as an IV formulation, the dose should be 2.2 g every 6- or 8-hourly, as suggested by the most recent study 1.
Key Considerations
- The IV formulation of amoxicillin-clavulanate is not commonly used, and instead, ampicillin-sulbactam (Unasyn) is used intravenously.
- However, based on the study by 1, a dose of 2.2 g every 6- or 8-hourly may be considered in critically ill patients receiving renal replacement therapy.
- It is essential to note that dosing should be adjusted for patients with renal impairment, with reduced frequency for creatinine clearance below 30 mL/min.
- The medication combines a beta-lactam antibiotic (ampicillin) with a beta-lactamase inhibitor (sulbactam) to overcome bacterial resistance mechanisms.
Important Points to Consider
- The IV route is used when oral therapy is not appropriate, such as in severe infections, inability to take oral medications, or when rapid therapeutic levels are needed.
- Common indications include intra-abdominal infections, skin and soft tissue infections, pneumonia, and gynecological infections.
- Monitor for allergic reactions, especially in patients with penicillin allergies.
- The study by 1 highlights the need for careful consideration of antibiotic dose and frequency in critically ill patients receiving renal replacement therapy.