From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
Luliconazole is more effective than terbinafine for the treatment of certain fungal infections, particularly dermatophyte infections like tinea pedis, tinea cruris, and tinea corporis, due to its broader spectrum of activity and higher skin concentrations. The choice between luliconazole and terbinafine should consider the specific fungal infection being treated, patient factors, cost considerations, and local availability. Luliconazole 1% cream is typically applied once daily for 1-2 weeks, while terbinafine 1% cream is usually applied once or twice daily for 1-4 weeks depending on the infection.
- Key benefits of luliconazole include:
- Broader spectrum of activity against dermatophytes, yeasts, and molds
- Higher skin concentrations and longer retention time in the stratum corneum
- Effective with once-daily dosing
- Generally well-tolerated with minimal side effects
- However, terbinafine may be preferred for certain infections like onychomycosis (nail fungus) where its fungicidal action against dermatophytes is particularly valuable 1, 2.
- A recent study published in 2022 found that luliconazole has strong fungicidal activity against Trichophyton spp., similar to that of terbinafine, and its antifungal activity is at par or even better than that of terbinafine 3.
- Another study published in 2016 demonstrated that luliconazole 1% cream applied once daily for 2 weeks successfully resolved the clinical signs and symptoms as well as eradicated the pathologic fungi that cause tinea pedis 2.
- Overall, the evidence suggests that luliconazole is a effective treatment option for certain fungal infections, and its benefits and drawbacks should be carefully considered when making treatment decisions 1, 3, 2.