From the Research
Normal IGF-1 levels for a 50-year-old female typically range from 87-238 ng/mL, with a Z-score between -2 and +2 considered within normal limits, as supported by the most recent study on IGF1 signaling pathways 1.
IGF-1 Levels and Z-Score
- A Z-score of 0 represents the population mean, while scores above or below indicate how many standard deviations a value is from the mean.
- The IGF1 signaling pathway plays a crucial role in growth, development, and metabolism, and its dysregulation has been implicated in various diseases, including cancer and cardiovascular disorders 1.
- The effects of IGF1 are moderated by a group of binding proteins (IGFBPs) that bind and transport the ligand in the circulation and extracellular fluids.
MTHFR Gene Mutations and ACTH/Cortisol Levels
- MTHFR gene mutations generally do not directly affect ACTH and cortisol levels, as the MTHFR gene encodes an enzyme involved in folate metabolism and methylation processes, while ACTH and cortisol are part of the hypothalamic-pituitary-adrenal axis that regulates stress response 2.
- Although methylation is important for many bodily functions, there is no established direct mechanism by which MTHFR variants would significantly alter ACTH or cortisol production or regulation.
- If you're experiencing symptoms suggesting abnormal cortisol levels, these are more likely related to other factors such as stress, pituitary or adrenal disorders, or medication effects rather than MTHFR status.
Clinical Implications
- Any concerns about hormone levels should be discussed with an endocrinologist who can provide appropriate testing and interpretation based on your specific health situation.
- The IGF1 receptor signaling pathways required for the induction of various bioactivities of IGFs, including cell proliferation, cell differentiation, and cell survival, are well-established 3.
- The modulation of IGF signals by other extracellular stimuli or by themselves is an area of ongoing research, with potential implications for the development of therapeutic strategies targeting the IGF1 signaling pathway 1.