Differential Diagnosis for Restless Leg Symptoms
- Single most likely diagnosis
- Restless Legs Syndrome (RLS): This is the most likely diagnosis due to the specific mention of restless leg symptoms, which is a hallmark of RLS. It is a common condition characterized by an irresistible urge to move the legs, usually accompanied by uncomfortable sensations.
- Other Likely diagnoses
- Periodic Limb Movement Disorder (PLMD): Often associated with RLS, PLMD involves involuntary movements of the legs during sleep, which can cause restless leg symptoms.
- Iron Deficiency: Iron deficiency, even without anemia, can cause symptoms of RLS, making it a likely consideration in patients with restless leg symptoms.
- Peripheral Neuropathy: Conditions affecting the nerves, such as diabetes, can lead to symptoms similar to RLS, including pain, numbness, and tingling in the legs.
- Medication-induced Akathisia: Certain medications, particularly antipsychotics and antidepressants, can cause akathisia, characterized by restlessness and an inability to sit still, which might be mistaken for restless leg symptoms.
- Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
- Deep Vein Thrombosis (DVT): Although less common, DVT can cause leg pain and restlessness, especially if the clot is large. Missing this diagnosis could lead to pulmonary embolism, which is potentially fatal.
- Peripheral Artery Disease (PAD): Severe PAD can cause claudication, which is pain in the legs during walking that stops when resting. In severe cases, it might lead to restlessness due to pain.
- Rare diagnoses
- Neurodegenerative Diseases (e.g., Parkinson's Disease): In rare cases, neurodegenerative diseases can present with restless leg symptoms among other neurological signs.
- Renal Failure: Advanced renal disease can lead to secondary hyperparathyroidism, which might cause restless leg symptoms due to alterations in calcium and phosphate metabolism.
- Vitamin B12 Deficiency: Similar to iron deficiency, a deficiency in vitamin B12 can lead to neurological symptoms, including those resembling RLS.