From the Guidelines
The daily dosing frequency of Tranexamic acid (TXA) is every 8 hours, which translates to 3 times a day for oral administration, or every 6 hours for intravenous administration 1.
- The recommended dosage of TXA can vary depending on the specific condition being treated, with dosages ranging from 500 mg twice daily to 1000 mg 4 times daily or 1500 mg 3 times daily for the management of epistaxis 1.
- For trauma patients, a loading dose of 1 g infused over 10 minutes, followed by an intravenous infusion of 1 g over 8 hours, is recommended 1.
- It is essential to note that the dosing frequency and duration of therapy may vary depending on the specific clinical context and the patient's response to treatment.
- The maximum daily dose should not exceed 3900 mg for oral administration, although this may vary depending on the specific clinical guidelines and patient population.
- TXA should be administered as early as possible to the trauma patient who is bleeding or at risk of significant hemorrhage, with treatment administered within 3 hours of injury showing the most significant reduction in the risk of death due to bleeding 1.
From the FDA Drug Label
The recommended dose of Tranexamic acid is ... 10 mg/kg actual body weight 3 to 4 times daily, intravenously. For patients with moderate to severe impaired renal function, the following dosages are recommended: * 1.36 to 2.83 (120 to 250 micromol/L) 10 mg/kg twice daily * 2.83 to 5. 66 (250 to 500 micromol/L) 10 mg/kg daily * >5.66 (>500 micromol/L) 10 mg/kg every 48 hours or 5 mg/kg every 24 hours
The daily dosing frequency of Tranexamic acid (TXA) is:
- 3 to 4 times daily for patients with normal renal function
- twice daily for patients with moderate renal impairment (serum creatinine 1.36 to 2.83 mg/dL)
- daily for patients with moderate to severe renal impairment (serum creatinine 2.83 to 5.66 mg/dL)
- every 48 hours or daily for patients with severe renal impairment (serum creatinine >5.66 mg/dL) 2
From the Research
Daily Dosing Frequency of Tranexamic Acid (TXA)
- The daily dosing frequency of Tranexamic Acid (TXA) can vary depending on the specific formulation and the condition being treated 3, 4, 5, 6, 7.
- According to a study published in the American Journal of Therapeutics, the optimum dosage regimen for TXA was 1.3 g every 8 hours, or 3 times daily, for up to 5 days 3.
- Another study published in The Annals of Pharmacotherapy states that TXA can be taken for up to 5 days per cycle, with the specific dosing frequency not specified 4.
- A review of TXA for the management of menorrhagia published in the journal Drugs suggests that TXA can be taken at a dose of 1.5 g three times daily for 5 days 5.
- A randomized controlled trial published in Obstetrics and Gynecology found that TXA 3.9 g/d was effective in reducing menstrual blood loss, with the medication taken for up to 5 days per menstrual cycle 6.
- A dose-response study published in the American Journal of Obstetrics and Gynecology found that TXA 3.9 g/d was the most effective dose in reducing menstrual blood loss, with the medication taken for up to 5 days of menstrual bleeding 7.