From the Guidelines
Zithromax (azithromycin) can cause several side effects, though most people tolerate it well, with common side effects including diarrhea, nausea, abdominal pain, and vomiting, as reported in a study published in 2017 1. The side effects of Zithromax are generally mild and temporary, but can include more serious reactions such as allergic reactions, irregular heartbeat, and QT interval prolongation.
- Common side effects of Zithromax include:
- Diarrhea
- Nausea
- Abdominal pain
- Vomiting
- Less common but more serious side effects include:
- Allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing)
- Irregular heartbeat
- Severe diarrhea
- Yellowing of eyes/skin
- Hearing changes
- QT interval prolongation, a heart rhythm problem that's more likely in people with certain heart conditions or those taking other medications that affect heart rhythm, as noted in a study published in 2020 1. It's essential to note that the risk of side effects may vary depending on the individual and the condition being treated.
- A study published in 2016 1 reported that macrolide antibiotics, including azithromycin, can cause gastrointestinal disturbances, cardiac conduction abnormalities, and rarely hepatotoxicity.
- Another study published in 2020 1 found that long-term treatment with macrolides, including azithromycin, can be associated with several adverse effects, including gastrointestinal side effects, hearing impairment, and cardiovascular events. If you experience severe or persistent side effects while taking Zithromax, it's crucial to contact your healthcare provider immediately.
- Most side effects resolve once the medication is completed, typically after a 3-5 day course depending on the condition being treated, as reported in a study published in 2017 1.
From the FDA Drug Label
ADVERSE REACTIONS SECTION In clinical trials, most of the reported side effects were mild to moderate in severity and were reversible upon discontinuation of the drug. Potentially serious side effects of angioedema and cholestatic jaundice were reported rarely. ... ClinicalAdultsMultiple-dose regimens Overall, the most common treatment-related side effects in adult patients receiving multiple-dose regimens of azithromycin were related to the gastrointestinal system with diarrhea/loose stools (4 to 5%), nausea (3%) and abdominal pain (2 to 3%) being the most frequently reported ... The types of side effects in pediatric patients were comparable to those seen in adults, with different incidence rates for the dosage regimens recommended in pediatric patients
The most common side effects of Zithromax (azithromycin) include:
- Gastrointestinal issues such as:
- Diarrhea/loose stools
- Nausea
- Abdominal pain
- Vomiting
- Other possible side effects include:
- Allergic reactions like rash, pruritus, and angioedema
- Cardiovascular issues like palpitations and chest pain
- Nervous system problems like dizziness and headache
- General issues like fatigue and fever 2