From the Guidelines
There is no significant difference in efficacy between Dexilant 60mg and 30mg for symptom control and tissue healing, as stated in the studies 1. The provided evidence does not directly compare the efficacy of Dexilant 60mg and 30mg. However, it mentions that any PPI, including dexlansoprazole, may be used because absolute differences in efficacy for symptom control and tissue healing are small 1. The studies focus on the use of upper endoscopy in patients with gastroesophageal reflux disease (GERD) and the appropriate use of proton pump inhibitors (PPIs) in these patients. Some key points from the evidence include:
- In most patients with typical GERD symptoms, an initial trial of empirical acid-suppressive therapy with once-daily PPIs is warranted, and endoscopy is not indicated 1.
- If 4 to 8 weeks of twice-daily empirical PPI therapy is unsuccessful, further investigation with endoscopy is recommended 1.
- Any PPI, including dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, or rabeprazole, may be used because absolute differences in efficacy for symptom control and tissue healing are small 1. It's essential to consult a healthcare provider to determine the appropriate dose of Dexilant based on individual medical needs, as the optimal dose depends on the specific condition, its severity, and response to treatment.
From the FDA Drug Label
Dexlansoprazole 60 mg capsules once daily was studied and did not provide additional clinical benefit over dexlansoprazole 30 mg capsules once daily Dexlansoprazole 90 mg once daily was studied and did not provide additional clinical benefit over dexlansoprazole 60 mg once daily Dexlansoprazole 60 mg capsules once daily was studied and provided no additional clinical benefit over dexlansoprazole 30 mg capsules once daily
No significant difference between dexilant 60mg and 30mg in terms of clinical benefit.
- The studies showed that dexlansoprazole 30 mg capsules were sufficient to provide statistically significant benefits compared to placebo.
- Dexlansoprazole 60 mg capsules did not provide any additional clinical benefit over the 30 mg dose. 2 2
From the Research
Comparison of Dexilant 60mg vs 30mg
- The provided studies do not directly compare the efficacy of Dexilant 60mg vs 30mg.
- However, a study 3 compared the efficacy of lansoprazole 30mg and dexlansoprazole 60mg in patients with atypical symptoms of gastroesophageal reflux disease (GERD).
- The study found that dexlansoprazole 60mg had a significantly higher response rate than lansoprazole 30mg in treating cough and globus symptoms.
- Another study 4 discussed the treatment of gastroesophageal reflux disease, including the use of proton pump inhibitors (PPIs) such as dexlansoprazole, but did not specifically compare the efficacy of different doses.
- Studies 5, 6, and 7 discussed various aspects of gastroesophageal reflux disease, including nonerosive reflux disease, asymptomatic erosive esophagitis, and the relationship between heartburn severity and erosive esophagitis severity, but did not provide information on the comparison of Dexilant 60mg vs 30mg.