Can a COVID-19 vaccine be administered during an acute asthma exacerbation, especially if the patient is symptomatic or receiving systemic corticosteroids?

COVID-19 Vaccination During Acute Asthma Exacerbation

Defer COVID-19 vaccination until the acute asthma exacerbation has resolved and the patient has recovered from acute symptoms. While asthma itself is not a contraindication to vaccination, administering the vaccine during an acute exacerbation is not recommended due to the difficulty in distinguishing vaccine-related adverse effects from worsening respiratory symptoms and the theoretical concern about suboptimal immune response during acute illness 1.

Key Principles for Timing

When to Defer Vaccination

• Active symptoms: Postpone vaccination until the patient has recovered from the acute exacerbation and respiratory symptoms have stabilized 1
• Systemic corticosteroid use: The evidence regarding high-dose corticosteroids (≥20 mg prednisone equivalent daily) and vaccination timing shows no consensus was reached among expert panels about whether to delay vaccination 2
• However, for patients receiving high-dose or long-term corticosteroid treatment in other contexts, vaccination is recommended 4-6 weeks after cessation of treatment 2

When Vaccination Can Proceed

• Well-controlled asthma: Patients with stable, well-controlled asthma should receive COVID-19 vaccination without delay 3, 4
• Maintenance therapy: Patients on inhaled corticosteroids, biologics (including dupilumab, omalizumab, mepolizumab), or low-dose systemic steroids (<20 mg prednisone equivalent) can be vaccinated without timing modifications 2, 4
• After recovery: Once acute symptoms resolve and the patient discontinues isolation (if applicable), proceed with vaccination without unnecessary delay 1

Corticosteroid Considerations

The relationship between systemic corticosteroids and COVID-19 vaccination timing remains nuanced:

• Low-dose steroids (<20 mg prednisone equivalent daily): No modifications to vaccination timing needed 2
• High-dose steroids (≥20 mg prednisone equivalent daily): Expert consensus was not achieved on whether to delay vaccination 2
• The controversy stems from concerns about blunted vaccine response versus the need for protection in vulnerable patients 2
• In the context of acute exacerbations requiring burst steroids, the practical approach is to wait until the acute episode resolves rather than focusing solely on steroid dose 1

Special Considerations for Asthma Patients

Risk-Benefit Analysis

• Asthma patients overall do not have increased risk of severe COVID-19 compared to non-asthmatics, and vaccination is strongly recommended 3
• Adequate asthma control reduces exacerbation risk, including those triggered by respiratory infections 5
• Case reports document rare vaccine-induced asthma exacerbations, but these are exceptional and do not change the overall recommendation to vaccinate 6

Practical Algorithm

1. Assess current asthma status:

   • Acute exacerbation with active symptoms → Defer vaccination
   • Well-controlled on maintenance therapy → Proceed with vaccination
   • Recent exacerbation but now stable → Proceed with vaccination

2. Evaluate corticosteroid use:

   • Inhaled corticosteroids only → No delay needed 2
   • Low-dose oral steroids (<20 mg prednisone) → No delay needed 2
   • High-dose oral steroids (≥20 mg prednisone) → Clinical judgment required; consider waiting until dose reduced if disease control permits 2

3. Consider biologics:

   • All asthma biologics (anti-IgE, anti-IL-5, anti-IL-4Rα) → No contraindication, proceed with vaccination 4

Common Pitfalls to Avoid

• Vaccinating during active exacerbation: This makes it impossible to distinguish vaccine adverse effects from disease progression and may result in suboptimal immune response 1
• Unnecessarily delaying vaccination in stable patients: Well-controlled asthmatics on maintenance therapy (including biologics) should not have vaccination delayed 3, 4
• Discontinuing asthma controller medications: Continue all asthma maintenance therapies, including inhaled corticosteroids and biologics, around the time of vaccination 4
• Assuming asthma is a contraindication: Asthma is an indication FOR vaccination, not against it 3, 4

Bottom Line

The decision hinges on whether the patient has active, symptomatic disease. If the asthma exacerbation is acute and ongoing, defer vaccination until clinical stability is achieved. Once stable—regardless of maintenance medications including systemic corticosteroids at typical doses—proceed with vaccination promptly to ensure protection against COVID-19 1, 3, 4.