What causes epigastric pain after Roux-en-Y (Roux-en-Y gastric bypass) surgery?

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Last updated: April 23, 2025View editorial policy

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Differential Diagnosis for Epigastric Pain after Roux-en-Y

  • Single most likely diagnosis:
    • Gastrogastric fistula: This condition is a known complication of Roux-en-Y gastric bypass surgery, where a fistula forms between the stomach pouch and the remnant stomach, leading to epigastric pain, among other symptoms.
  • Other Likely diagnoses:
    • Marginal ulcer: Ulcers at the margin of the gastric pouch or the anastomosis site can cause epigastric pain and are a common issue post-Roux-en-Y surgery.
    • Anastomotic stricture: Narrowing of the anastomosis site can lead to obstructive symptoms and pain.
    • Gastritis: Inflammation of the stomach lining, which can be exacerbated by the altered anatomy post-surgery.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.):
    • Bowel obstruction: Although less common, obstruction of the bowel at the anastomosis site or due to adhesions can lead to severe consequences if not promptly addressed.
    • Leaks: Anastomotic leaks are a serious complication that can present with epigastric pain and require immediate intervention.
    • Hemorrhage: Bleeding from the anastomosis site or from ulcers can be life-threatening.
  • Rare diagnoses:
    • Intussusception: A condition where a part of the intestine telescopes into another part, which can cause obstruction and pain.
    • Chronic mesenteric ischemia: Reduced blood flow to the intestines, which can cause abdominal pain, including epigastric pain, though it's less common post-Roux-en-Y.
    • Bezoar: A mass of food or other material that can obstruct the stomach or small intestine, potentially causing pain.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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