In an adult with no known medical history presenting with chest pain, headache, dizziness, blurred vision, and neck pain, what is the appropriate immediate management?

Immediate Management of Suspected Hypertensive Emergency

This patient requires immediate emergency department evaluation by EMS—the constellation of chest pain, headache, dizziness, blurred vision, and neck pain strongly suggests a hypertensive emergency with acute end-organ damage until proven otherwise. 1

Life-Threatening Conditions to Exclude First

Hypertensive Emergency with End-Organ Damage

• Measure blood pressure immediately in both arms—hypertensive emergency is defined as BP ≥180/110 mmHg with acute hypertension-mediated organ damage (HMOD), presenting with headache, visual disturbances, chest pain, dizziness, and neurological deficits. 1
• This symptom cluster (headache + visual disturbances + chest pain + dizziness) is the classic presentation of hypertensive encephalopathy or malignant hypertension with acute microangiopathy affecting the brain, retina, and potentially the heart. 1
• Malignant hypertension causes small-artery fibrinoid necrosis in kidneys, retina, and brain, characterized by retinopathy (flame hemorrhages, cotton wool spots, papilloedema), encephalopathy (~15% of cases), and acute heart failure. 1

Acute Aortic Dissection

• Sudden-onset "ripping" or "tearing" chest pain radiating to the neck or back is the hallmark of aortic dissection, which can present with headache when the dissection extends proximally to involve carotid arteries. 1, 2
• Check for pulse differentials between all four extremities and blood pressure differences >20 mmHg between arms—present in ~30% of dissections. 1, 3
• Neck pain combined with chest pain and headache raises concern for proximal aortic dissection extending to the carotid arteries, which is life-threatening and requires vastly different treatment than isolated cervical artery dissection. 2

Acute Coronary Syndrome (ACS)

• Chest pain with associated symptoms (dizziness, diaphoresis, dyspnea, nausea) significantly increases ACS likelihood—obtain a 12-lead ECG within 10 minutes and measure high-sensitivity cardiac troponin immediately. 1, 4
• Retrosternal pressure, squeezing, or heaviness that builds over minutes and radiates to the neck or jaw is typical of ACS. 1, 4
• A normal physical examination does NOT exclude acute myocardial infarction—uncomplicated MI can present with entirely normal findings. 4, 3

Posterior Circulation Stroke

• Headache, dizziness, blurred vision, and neck pain can represent vertebrobasilar insufficiency or posterior circulation stroke, especially in the setting of severe hypertension or vertebral artery dissection. 1, 2

Mandatory Immediate Actions (First 10 Minutes)

Vital Signs and Physical Examination

• Measure blood pressure in both arms and assess for pulse differentials to detect aortic dissection or asymmetric perfusion. 1, 3
• Assess heart rate, respiratory rate, and oxygen saturation—tachycardia >100 bpm or bradycardia <50 bpm indicates hemodynamic instability requiring urgent intervention. 1
• Perform fundoscopic examination to identify papilledema, flame hemorrhages, or cotton wool spots indicative of malignant hypertension. 1
• Neurological examination to detect focal deficits, altered mental status, somnolence, or signs of encephalopathy—focal lesions are rare in hypertensive encephalopathy and should raise suspicion for stroke. 1
• Cardiovascular examination for new murmurs (aortic regurgitation suggests dissection), S3 gallop (heart failure), or pericardial friction rub. 1, 3

Diagnostic Testing

• 12-lead ECG within 10 minutes to identify STEMI, ST-depression, T-wave inversions, or left ventricular hypertrophy patterns. 1, 4
• High-sensitivity cardiac troponin immediately—most sensitive biomarker for myocardial injury even when ECG is normal. 1, 4, 5
• If ECG shows ST-elevation or new ischemic changes, activate STEMI protocol immediately with door-to-balloon time <90 minutes or door-to-needle <30 minutes. 1, 4

Emergency Medical Services Transport

• Call EMS immediately—do NOT transport by personal automobile—EMS can perform pre-hospital ECG, administer aspirin, provide defibrillation, manage arrhythmias, and reduce travel time. 1, 4
• Administer aspirin 162-325 mg (chewed, not swallowed) immediately unless contraindicated by known allergy or active gastrointestinal bleeding. 1, 4, 5
• Provide sublingual nitroglycerin unless systolic BP <90 mmHg or heart rate <50 or >100 bpm—but withhold if aortic dissection is suspected. 1, 4
• Intravenous morphine 4-8 mg for pain relief if ACS is suspected, as pain increases sympathetic activation and myocardial oxygen demand. 4

Emergency Department Evaluation

If Hypertensive Emergency Confirmed

• Initiate careful intravenous antihypertensive therapy to reduce BP—hypertensive emergencies are potentially life-threatening and require immediate intervention, often with IV therapy. 1
• Avoid beta-blockers if sympathomimetic drug use (methamphetamine, cocaine) is suspected—can precipitate unopposed alpha-adrenergic stimulation. 1
• Admit to intensive care unit for continuous cardiac monitoring and frequent neurological assessments. 1

If Aortic Dissection Suspected

• Obtain immediate CT angiography or transesophageal echocardiography to confirm diagnosis. 3, 2
• Withhold aspirin, heparin, and all antithrombotic therapy until dissection is excluded. 3
• Transfer to a center with 24/7 cardiac surgery capability if dissection is confirmed. 3

If ACS Confirmed

• Elevated troponin (≥99th percentile) without ST-elevation: admit to coronary care unit, initiate dual antiplatelet therapy (aspirin + P2Y12 inhibitor), anticoagulation, and plan urgent coronary angiography. 4, 5
• Serial troponin at 3-6 hours if initial value is negative—a single normal troponin does NOT exclude ACS. 4, 5

Critical Pitfalls to Avoid

• Do NOT delay EMS transport for additional testing or troponin measurement in office settings—immediate transfer is essential when clinical evidence of life-threatening causes exists. 1, 4
• Do NOT rely on nitroglycerin response to differentiate cardiac from non-cardiac chest pain—esophageal spasm and other conditions also respond. 1, 4, 3
• Do NOT assume young age or absence of risk factors excludes serious disease—hypertensive emergencies, dissections, and ACS can occur at any age. 1, 4, 6
• Do NOT dismiss symptoms as anxiety or tension headache without objective testing—this symptom constellation mandates exclusion of hypertensive emergency, dissection, and ACS. 1, 4
• A normal initial ECG does NOT exclude ACS—30-40% of acute myocardial infarctions present with a normal or nondiagnostic ECG. 1, 4

Special Considerations

• Women are at higher risk for underdiagnosis of ACS and more frequently present with accompanying symptoms (headache, nausea, dizziness) rather than classic chest pain. 4, 3
• Patients with diabetes may present with atypical symptoms including vague complaints, confusion, or isolated dizziness without classic chest pain. 1, 4
• Neck pain combined with chest pain and headache is a rare but critical presentation that may indicate proximal aortic dissection extending to carotid arteries—differentiation from isolated cervical artery dissection is pivotal because treatment options are vastly different. 2