From the Guidelines
Ferrous sulfate should be dosed at 200 mg (65 mg elemental iron) orally once daily for adults with iron deficiency anemia, as this is a reasonable compromise option for initial treatment 1. The optimal dosage and timing of oral iron replacement therapy (IRT) for adults with iron deficiency anemia (IDA) are not clearly defined, but a once daily dose of 50–100 mg of elemental iron may be the best option 1. Key considerations for ferrous sulfate dosing include:
- Taking the medication on an empty stomach, 1 hour before or 2 hours after meals, to enhance absorption
- Avoiding concurrent intake of calcium, antacids, dairy, tea, coffee, or whole-grain foods, as these decrease absorption
- Considering administration with vitamin C (like orange juice) to enhance absorption
- Monitoring for common side effects, such as constipation, black stools, and stomach upset, and adjusting the dosing regimen as needed
- Continuing treatment for 3-6 months to replenish iron stores even after hemoglobin normalizes, although the optimal duration is unclear 1. It is essential to monitor the initial haematological response to ferrous sulfate and modify the treatment regimen as appropriate in cases of apparent therapeutic failure 1. In patients with significant intolerance to oral IRT, alternative options such as oral ferric maltol, alternate day oral iron, or parenteral iron may be considered 1. Regular hemoglobin monitoring is recommended to ensure an ultimately satisfactory response, with an optimal interval of every 4 weeks until the hemoglobin is in the normal range 1.
From the FDA Drug Label
CONTAINS: Each tablet contains 324 mg of ferrous sulfate, equivalent to 65 mg of elemental iron, providing 362% of the U.S. recommended daily intake (RDI) of iron for adults and children 4 and older.
16 HOW SUPPLIED Ferrous Sulfate Tablets are available as follows: Each tablet contains 324mg of ferrous sulfate, equivalent to 65mg of elemental iron, providing 362% of the U.S. recommended daily intake (RDI) of iron for adults and children 4 and older.
The dosage of ferrous sulfate is not explicitly stated in the provided drug labels. The labels only provide information on the composition of each tablet, which contains 324 mg of ferrous sulfate, equivalent to 65 mg of elemental iron 2 2.
From the Research
Ferrous Sulfate Dosing
There are no research papers to assist in answering this question about ferrous sulfate dosing, as the provided study 3 discusses the total condylar knee prosthesis and its application in knee deformities, with no mention of ferrous sulfate or its dosing.
- The study 3 focuses on the outcomes of 220 arthroplasties in 183 patients, using the total condylar knee prosthesis.
- It reports on the assessment of patients using The Hospital for Special Surgery scoring system, with 62% of knees rated as excellent and 28% as good.
- Complications and reoperation rates are also discussed in the study 3, but there is no relevant information on ferrous sulfate dosing.