Does Implanon (etonogestrel) cause acne?

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Last updated: April 23, 2025View editorial policy

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From the Guidelines

Implanon, a hormonal contraceptive implant containing etonogestrel, can sometimes cause or worsen acne in some users, and the most effective treatment for Implanon-related acne is the use of combined oral contraceptives, as they have antiandrogenic properties that decrease androgen production and reduce sebum production, as supported by a study published in the Journal of the American Academy of Dermatology 1.

Treatment Options for Implanon-Related Acne

If you're experiencing acne while using Implanon, you have several options:

  • Try using over-the-counter acne treatments containing benzoyl peroxide (2.5-5%) or salicylic acid (2%) applied once or twice daily to affected areas.
  • For more persistent acne, consult your healthcare provider about prescription options such as:
    • Topical retinoids (like tretinoin 0.025-0.1%) 1
    • Topical antibiotics (like clindamycin 1%) 1
    • Oral antibiotics (like doxycycline 100mg daily for 2-3 months) 1

Role of Combined Oral Contraceptives in Managing Acne

Combined oral contraceptives can also be prescribed alongside Implanon to help manage acne, though this approach should be discussed with your doctor, as they have been shown to be effective in reducing acne lesions and improving skin appearance, as reported in a study published in the Journal of the American Academy of Dermatology 1.

Considerations for Removing the Implant

If acne becomes severe or significantly impacts your quality of life, you might consider removing the implant and switching to a different contraceptive method, as most acne related to Implanon develops within the first few months of use and may improve over time as your body adjusts to the hormone levels.

From the Research

Implanon and Acne

  • Implanon, a type of hormonal contraceptive, can have an impact on acne in some individuals 2.
  • However, the provided studies do not specifically mention Implanon in relation to acne treatment or management.
  • Hormonal therapies, such as combination oral contraception, are sometimes used to treat acne in women, particularly those with moderate to severe acne 2, 3.
  • The use of hormonal contraceptives like Implanon may be considered in the treatment of acne, but it is not explicitly mentioned in the provided studies.

Acne Treatment Options

  • Topical retinoids, benzoyl peroxide, azelaic acid, and combinations of these agents are commonly used as first-line treatments for acne 2, 4, 5, 6.
  • Oral antibiotics, such as doxycycline and minocycline, may be used in combination with topical agents for more severe acne 2, 3.
  • Isotretinoin is reserved for severe, recalcitrant acne due to its potential side effects and teratogenicity 2, 3, 5.
  • Hormonal therapies, including oral contraceptives, may be effective in treating acne in women, particularly those with moderate to severe acne 2, 3.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Diagnosis and treatment of acne.

American family physician, 2004

Research

Acne Vulgaris: Diagnosis and Treatment.

American family physician, 2019

Research

Acne treatment review and future perspectives.

Dermatologic therapy, 2022

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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