What are the health risks associated with Red 40 (Allura Red AC)?

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Last updated: February 16, 2025 • View editorial policy

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From the Research

Health Risks Associated with Red 40 (Allura Red AC)

  • Red 40, a synthetic food dye, has been linked to various health concerns, including:
    • Hyperactivity in children 1, 2
    • Allergic reactions and hypersensitivity 3, 4
    • Potential carcinogenic effects, as it has been found to be contaminated with benzidine or other carcinogens 4
    • Neurobehavioral toxicity, which may contribute to attention-deficit/hyperactivity disorder (ADHD) symptoms 1, 3, 2
  • The exact mechanisms by which Red 40 exerts its effects are not fully understood, but it is thought to involve the activation of the inflammatory cascade, induction of intestinal permeability, and disruption of the immune system 3
  • Some studies suggest that restriction diets excluding artificial food colorings, including Red 40, may affect symptom severity in children with ADHD or hyperactive syndromes 5, 2
  • Regulatory authorities have been criticized for their approval of Red 40 and other synthetic food dyes, with some arguing that better and independent toxicity testing is needed to ensure their safety 4

References

1
Research

Food Color and Autism: A Meta-Analysis.

Advances in neurobiology, 2020

3
Research

Immune reactivity to food coloring.

Alternative therapies in health and medicine, 2015

4
Research

Toxicology of food dyes.

International journal of occupational and environmental health, 2012

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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