What causes an ulcer on the uvula (uvular ulcer)?

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Last updated: April 24, 2025View editorial policy

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From the Guidelines

Ulcers on the uvula are most commonly caused by viral infections, with herpes simplex virus, coxsackievirus, and Epstein-Barr virus being frequent culprits, as well as bacterial infections like strep throat, as noted in the context of acute pharyngitis 1. When considering the etiology of uvular ulcers, it's essential to recognize that viral infections are a prevalent cause, often presenting with additional symptoms such as sore throat, fever, and headache. Bacterial infections, including Group A streptococcal (GAS) pharyngitis, can also lead to uvular ulceration, characterized by tonsillopharyngeal erythema, anterior cervical lymphadenitis, and a beefy red swollen uvula 1. Key factors to consider in the diagnosis of uvular ulcers include:

  • Clinical presentation, such as sudden onset of sore throat, pain on swallowing, and fever
  • Presence of other symptoms like abdominal pain, nausea, vomiting, and headache
  • Physical examination findings, including tonsillopharyngeal erythema, exudates, and cervical lymphadenitis
  • Microbiological confirmation through throat culture or rapid antigen detection test (RADT) for GAS pharyngitis 1 Given the potential causes and the importance of accurate diagnosis, treatment should be tailored to the underlying cause, with viral infections often resolving on their own, bacterial infections requiring antibiotics, and other causes addressed accordingly.

From the Research

Causes of Ulcer on Uvula

There are no research papers provided that directly discuss the causes of ulcers on the uvula.

Related Information

  • The provided studies focus on the use of amoxicillin and amoxicillin-clavulanic acid in treating various infections, such as urinary tract infections caused by extended-spectrum Beta-lactamase-producing organisms 2 and the properties, indications, and usage of oral amoxicillin and amoxicillin-clavulanic acid 3.
  • These studies do not mention ulcers on the uvula or their causes.
  • Possible causes of ulcers on the uvula may include:
    • Trauma or injury to the uvula
    • Infections, such as bacterial or viral infections
    • Allergic reactions or irritations
    • Other medical conditions, such as cancer or autoimmune disorders However, without direct evidence, it is not possible to provide a definitive answer to this question.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Oral amoxicillin and amoxicillin-clavulanic acid: properties, indications and usage.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2020

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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