What is the recommended administration of 100 mg hydrocortisone sodium succinate diluted in 10 mL normal saline as a rapid intravenous push for an adult requiring immediate glucocorticoid effect (e.g., adrenal crisis)?

Administration of IV Hydrocortisone 100mg in 10mL Saline as a Push

Hydrocortisone 100 mg diluted in 10 mL normal saline should be administered as an immediate IV bolus (push) in adrenal crisis, followed by continuous infusion of 200 mg over 24 hours until the patient is stable. 1

Immediate Administration Protocol

• Administer the entire 100 mg dose as a rapid IV bolus without delay in suspected or confirmed adrenal crisis—do not wait for diagnostic confirmation, as treatment is time-critical 1, 2
• The 100 mg bolus can be given over several minutes as a direct push through established IV access 3
• If peripheral venous access cannot be achieved quickly, switch immediately to intramuscular administration rather than delaying treatment 4

Post-Bolus Management

• After the initial 100 mg bolus, immediately start a continuous IV infusion of hydrocortisone 200 mg over 24 hours until hemodynamic stability is achieved 1, 2, 5
• Simultaneously administer 1000 mL of 0.9% normal saline within the first hour to address the profound volume depletion characteristic of adrenal crisis 2
• Continue aggressive fluid resuscitation with crystalloids (up to 7 L may be necessary in adults), initially at 5-10 mL/kg in the first 5 minutes 3

Clinical Context and Rationale

• This 100 mg bolus represents 4-5 times the normal daily replacement dose and provides the supraphysiologic glucocorticoid levels needed to counteract the life-threatening inflammatory cascade of adrenal crisis 6
• The rapid administration is essential because adrenal crisis patients present with profoundly impaired well-being, hypotension, nausea, vomiting, and fever that respond well to immediate parenteral hydrocortisone 2
• Hydrocortisone sodium succinate converts rapidly to active hydrocortisone in plasma with a half-life of only 5.38 minutes, reaching peak hydrocortisone concentrations within 10 minutes of IV administration 7

Critical Pitfalls to Avoid

• Never delay hydrocortisone administration to obtain diagnostic blood work—draw cortisol and ACTH levels before treatment if possible, but do not postpone the bolus if venous access is already established 1
• Do not use lactated Ringer's solution for initial resuscitation, as it may contribute to metabolic acidosis; use only 0.9% normal saline 3
• Monitor patients with congestive heart failure or chronic renal disease cautiously during aggressive fluid resuscitation to prevent volume overload 3

Alternative Scenarios

• For perioperative stress coverage (not acute crisis), a single 100 mg IV/IM dose at induction is sufficient for minor procedures, with postoperative doubling of oral doses for 24 hours 1
• For major surgery, give 100 mg at induction followed by 100 mg every 6 hours for 24-48 hours, then transition to doubled oral doses 1