Differential Diagnosis for IV Antibiotic Induced Autoimmune Uricaria
- Single Most Likely Diagnosis
- Autoimmune Urticaria: This condition is characterized by the body's immune system attacking its own tissues, leading to the release of histamine and other chemical mediators, causing hives. The fact that hives occur during any sickness and the luteal phase of the menstrual cycle suggests an autoimmune component triggered by various factors, including hormonal changes and immune system activation during illness.
- Other Likely Diagnoses
- Allergic Intercurrent Disease: This refers to the exacerbation of allergic symptoms, such as urticaria, during other illnesses due to increased histamine release or immune system dysregulation.
- Hormonal Urticaria: Fluctuations in hormone levels, particularly during the luteal phase of the menstrual cycle, can trigger or exacerbate urticaria in some individuals.
- Chronic Urticaria: This is a condition characterized by recurring hives with no identifiable cause, which could be exacerbated by the patient's history of IV antibiotic-induced autoimmune urticaria.
- Do Not Miss Diagnoses
- Hereditary Angioedema (HAE): Although rare, HAE can present with urticaria-like symptoms and is often triggered by stress, illness, or hormonal changes. Missing this diagnosis could be life-threatening due to the potential for airway obstruction.
- Mastocytosis: A condition characterized by the accumulation of mast cells in various tissues, which can lead to episodic release of histamine and other mediators, causing urticaria among other symptoms.
- Rare Diagnoses
- Schnitzler Syndrome: A rare autoimmune disorder characterized by chronic urticaria, bone pain, and a monoclonal gammopathy, which could be considered in the differential diagnosis of chronic urticaria with systemic symptoms.
- Cryopyrin-Associated Periodic Syndrome (CAPS): A group of rare autoinflammatory disorders that can present with urticaria-like rashes, among other symptoms, and are often triggered by cold temperatures or other factors.