What is the differential diagnosis for left lower quadrant pain?

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Last updated: February 16, 2025View editorial policy

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Differential Diagnosis for Left Lower Quadrant (LLQ) Pain

  • Single Most Likely Diagnosis
    • Diverticulitis: The most common cause of LLQ pain, especially in older adults, due to inflammation of the diverticula in the sigmoid colon.
  • Other Likely Diagnoses
    • Constipation: Can cause LLQ pain due to fecal impaction or straining during bowel movements.
    • Irritable Bowel Syndrome (IBS): A common condition characterized by abdominal pain, bloating, and changes in bowel habits.
    • Ovarian Cyst: Can cause LLQ pain in women, especially if the cyst ruptures or becomes twisted.
    • Ectopic Pregnancy: A life-threatening condition that can cause LLQ pain in women of childbearing age.
  • Do Not Miss Diagnoses
    • Appendicitis: Although more commonly associated with right lower quadrant pain, appendicitis can occasionally present with LLQ pain, especially if the appendix is retrocecal.
    • Intestinal Obstruction: A bowel obstruction can cause severe LLQ pain, nausea, vomiting, and constipation.
    • Inflammatory Bowel Disease (IBD): Conditions like Crohn's disease and ulcerative colitis can cause chronic LLQ pain, diarrhea, and weight loss.
    • Kidney Stone: A stone in the left ureter can cause severe LLQ pain, radiating to the groin.
  • Rare Diagnoses
    • Endometriosis: A condition in which tissue similar to the lining of the uterus grows outside the uterus, causing chronic LLQ pain.
    • Inguinal Hernia: A hernia in the groin area can cause LLQ pain, especially if it becomes incarcerated or strangulated.
    • Lymphoma: A type of cancer that can cause LLQ pain, weight loss, and fatigue.
    • Splenic Infarction: A rare condition in which the spleen becomes infarcted, causing severe LLQ pain.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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