Qelbree Capsule Count for Standard Adult Titration
For an adult starting Qelbree using the standard titration schedule, you would prescribe 30 capsules for a 30-day month.
Rationale for Dosing
The FDA-approved labeling for viloxazine extended-release (Qelbree) specifies once-daily oral administration 1. For adults, the standard approach involves:
- Starting dose: 200 mg once daily 2
- Titration: Flexible dose adjustment between 200-600 mg/day to achieve optimal efficacy and tolerability 2
- Dosing frequency: Once daily throughout treatment 1, 2
Capsule Calculation
Since Qelbree is administered once daily regardless of the dose strength used:
- 30 days × 1 capsule per day = 30 capsules total 1
The titration process involves adjusting the strength of the capsule (100 mg, 150 mg, or 200 mg capsules) rather than the number of capsules taken per day 1. Available strengths include 100 mg, 150 mg, and 200 mg capsules 1.
Clinical Context from Long-Term Studies
In the phase 3 open-label extension study of adults, viloxazine ER was initiated at 200 mg/day and adjusted between 200-600 mg/day during a dose-optimization period 2. Following initial optimization, 73% of adult participants used doses ≥400 mg/day, with 36% using 600 mg/day during maintenance treatment 2.
Important caveat: The "regular titration schedule" maintains the once-daily dosing regimen throughout, so regardless of whether a patient is on 200 mg, 400 mg, or 600 mg daily, they take one capsule per day 1, 2.