From the FDA Drug Label
The recommended dosage of VALTREX for treatment of cold sores is 2 grams twice daily for 1 day taken 12 hours apart. Therapy should be initiated at the earliest symptom of a cold sore (e.g., tingling, itching, or burning). The recommended dosage of VALTREX for the treatment of cold sores in pediatric patients aged greater than or equal to 12 years is 2 grams twice daily for 1 day taken 12 hours apart. Therapy should be initiated at the earliest symptom of a cold sore (e.g., tingling, itching, or burning).
The treatment dosing for cold sores with Valacyclovir is 2 grams twice daily for 1 day, taken 12 hours apart. Therapy should be initiated at the earliest symptom of a cold sore. This applies to both adults and pediatric patients aged 12 years and older 1 1.
- Key points:
- Dosage: 2 grams twice daily for 1 day
- Timing: 12 hours apart
- Initiation: At the earliest symptom of a cold sore
- Applicability: Adults and pediatric patients aged 12 years and older
From the Research
Valacyclovir for cold sores is typically prescribed as 2 grams taken twice daily for one day, with doses separated by about 12 hours, as this regimen has been shown to be safe and effective in reducing the duration and severity of the outbreak 2. This short-course therapy should be started at the earliest sign of a cold sore (tingling, itching, or burning) for maximum effectiveness. The medication works by converting to acyclovir in the body, which inhibits viral DNA replication and shortens the duration and severity of the outbreak. Some key points to consider when prescribing valacyclovir for cold sores include:
- The importance of starting treatment early, as this can help reduce the severity and duration of the outbreak
- The potential for valacyclovir to prevent or reduce the frequency of recurrent episodes, particularly in individuals with frequent recurrences (more than 6 episodes per year) 3
- The need for patients to maintain adequate hydration while taking valacyclovir and to complete the full prescribed course even if symptoms improve
- The potential for valacyclovir to be used in a suppressive regimen of 500 mg daily for individuals with frequent recurrences
- The importance of consulting a healthcare provider if cold sores occur frequently or are severe, as this could indicate an underlying immune system issue. It's also worth noting that valacyclovir has been shown to be well-tolerated and effective in reducing the rate of recurrent ocular HSV disease, with a similar safety profile to acyclovir 4. Overall, valacyclovir is a safe and effective treatment option for cold sores, and its use should be considered in individuals with frequent or severe outbreaks.