From the Research
Valacyclovir and kratom should not be taken together due to potential harmful interactions. Valacyclovir is an antiviral medication used to treat herpes infections, while kratom is an herbal supplement with opioid-like effects. When combined, these substances may increase the risk of side effects including dizziness, drowsiness, confusion, and difficulty concentrating. Additionally, both substances are processed by the liver, and taking them together could potentially strain liver function. Kratom may also reduce the effectiveness of valacyclovir by interfering with its absorption or metabolism. If you're prescribed valacyclovir, you should discontinue kratom use and inform your healthcare provider about any supplements you're taking. The safety profile of kratom is not well-established through clinical research, and it has been associated with serious adverse effects including seizures and liver damage in some cases 1.
Key Considerations
- The use of non-US Food and Drug Administration-approved substances of abuse, such as kratom, can have innate risks due to pharmacologic and pharmacokinetic properties of the medications 1.
- Valacyclovir is a well-tolerated drug with a favorable safety profile, and its efficacy in treating herpes infections has been established in several studies 2, 3, 4.
- The potential for drug interactions between valacyclovir and kratom is a concern, and patients should be advised to avoid taking these substances together.
- Patients taking valacyclovir should inform their healthcare provider about any supplements they're taking, including kratom, to minimize the risk of adverse effects.
Recommendations
- Discontinue kratom use if prescribed valacyclovir to minimize the risk of potential harmful interactions.
- Inform your healthcare provider about any supplements you're taking, including kratom.
- Consult with your healthcare provider before making any changes to your medication regimen if you're currently taking both substances.