No, Do Not Take an SSRI to Increase Your Sex Drive
SSRIs consistently cause sexual dysfunction—including decreased libido—in 40-90% of patients and should never be used to enhance sex drive. 1, 2
Why SSRIs Are Contraindicated for Libido Enhancement
SSRIs work by increasing serotonin, which directly suppresses sexual function through multiple mechanisms including delayed orgasm, decreased genital sensation, and reduced sexual desire. 3 This is the opposite of what you're seeking.
Sexual Dysfunction Rates by SSRI
The evidence shows all SSRIs cause significant sexual problems, though rates vary:
- Paroxetine: 70.7% - highest sexual dysfunction rate among all SSRIs 1, 2
- Escitalopram: 40-90% - depending on assessment method 1
- Sertraline: 14% ejaculatory failure, 6% decreased libido (likely underreported) 2
- Fluoxetine: moderate-high rates 2
These rates are vastly underreported in clinical trials, with actual real-world rates likely much higher. 2
Specific Sexual Side Effects You Would Experience
If you took an SSRI, you would likely develop:
- Decreased libido (reduced sexual desire) 3, 4
- Delayed or absent orgasm - the most common effect 1, 4
- Erectile dysfunction (in men) 1, 3
- Decreased genital sensation 5
- Reduced arousal and lubrication (in women) 3, 4
These effects are strongly dose-related and typically emerge within the first week of treatment. 1, 2
The Paradoxical Medical Use
SSRIs are actually prescribed to delay ejaculation in men with premature ejaculation precisely because they suppress sexual function. 1 This therapeutic use confirms that SSRIs have the exact opposite effect of what you want.
Risk of Persistent Sexual Dysfunction
A critical warning: Sexual dysfunction from SSRIs can persist indefinitely even after stopping the medication in a condition called Post-SSRI Sexual Dysfunction (PSSD). 5, 6 This means you could permanently damage your sexual function by taking an SSRI, with decreased capacity to experience sexual pleasure being the most frequent long-term complaint. 6
What You Should Consider Instead
If you're experiencing low libido, the appropriate evaluation includes:
- Check testosterone levels (total morning testosterone >300 ng/dL in men) - low testosterone independently causes decreased libido 2
- Evaluate for underlying depression - untreated depression itself causes low libido 7
- Consider psychosocial factors - relationship issues, stress, and interpersonal functioning affect sexual desire 3
- Referral to sexual health specialist for persistent symptoms 2
If Depression Is Present and Requires Treatment
If you have depression requiring medication and want to preserve sexual function, bupropion is the only antidepressant recommended as first-line therapy, with sexual dysfunction rates of only 8-10% compared to 40-90% with SSRIs. 2 Bupropion may actually increase libido in some patients. 2
Contraindications to bupropion: Do not use if you have seizure disorders or are highly agitated. 2
Critical Safety Warning
Never combine SSRIs with MAOIs due to risk of potentially fatal serotonin syndrome (symptoms: tremor, agitation, fever, seizures). 1 If you're already on any psychiatric medications, consult your physician before making changes.