Can IV paracetamol be administered to a patient who cannot take oral or rectal medication (e.g., NPO, severe vomiting, intubated), and what are the appropriate doses and contraindications?

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Last updated: February 21, 2026View editorial policy

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Oo, Pwede Magbigay ng IV Paracetamol

Oo, pwede at inirerekomenda ang IV paracetamol para sa mga pasyenteng hindi makakain ng oral o rectal na gamot (tulad ng NPO, nagsusuka, o naka-intubate). 1

Mga Indikasyon para sa IV Route

  • Ang IV paracetamol ay specifically indicated kapag ang oral route ay hindi feasible dahil sa NPO status, hindi kayang tumanggap ng oral medications, o kailangan ng mabilis na pain relief 1
  • Inirerekomenda ng American Society of Anesthesiologists ang IV paracetamol bilang first-line analgesic at antipyretic agent kapag ibibigay via IV route 1
  • Ginagamit ito sa postoperative settings tulad ng PACU at immediate postoperative period 1

Tamang Dosing

Para sa Matatanda:

  • Maintenance dose: 1 gram every 6-8 hours 1
  • Maximum daily dose: 4 grams sa loob ng 24 oras 1
  • Ang 10 mg/ml preparation ay specifically designed para sa IV infusion 1

Para sa Mga Bata:

  • Loading dose: 15-20 mg/kg IV 1
  • Maintenance dose: 10-15 mg/kg every 6-8 hours 1
  • Maximum daily dose: 60 mg/kg 1

Mga Kontraindikasyon at Babala

  • Huwag lumampas sa maximum daily dose (4 g sa adults, 60 mg/kg sa bata) para maiwasan ang hepatotoxicity 1
  • Kontraindikado sa mga pasyenteng may hepatic insufficiency 2
  • Kailangan ng dose adjustment consideration sa elderly at chronic renal insufficiency, kahit hindi palaging kailangan bawasan ang dose 2

Multimodal Analgesia Strategy

  • Dapat i-combine ang IV paracetamol sa ibang non-opioid analgesics tulad ng NSAIDs o COX-2 selective inhibitors para sa optimal pain control at para mabawasan ang opioid requirements 1
  • Ang combination ng paracetamol at NSAIDs ay may Grade A recommendation para sa postoperative use 1
  • Para sa pediatric patients: Simulan ng IV paracetamol 15 mg/kg + IV ibuprofen 10 mg/kg, pagkatapos reassess ang pain sa 30-60 minutes 3

Transition sa Oral Route

  • Mag-transition sa oral paracetamol as soon as possible kapag kaya na ng pasyente ang oral intake 1
  • Ang American Society of Anesthesiologists ay nagsasabing gamitin ang IV paracetamol sa first 24 hours after surgery, pagkatapos lumipat sa oral kapag kaya na 1
  • Iwasan ang unnecessary continuation ng IV paracetamol para hindi masayang ang resources at para maalis na ang IV access 1
  • Kapag nasa ward na ang pasyente at intact na ang gastrointestinal function, equivalent na ang efficacy ng oral paracetamol sa IV 1

Common Pitfalls na Iwasan

  • Huwag magpatuloy ng IV paracetamol nang walang dahilan—mag-transition agad sa oral route kapag tolerated na 1
  • Huwag kalimutang i-monitor ang total daily dose mula sa lahat ng sources ng paracetamol para hindi ma-exceed ang maximum 1
  • Kung inadequate pa rin ang pain control, magdagdag ng NSAID (ibuprofen 400 mg every 8 hours, max 1200 mg/day) bago mag-escalate sa opioids 4

References

Guideline

Intravenous Paracetamol Administration Guidelines

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Guideline

Management of Abdominal Pain in Children

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Guideline

Escalation of Analgesia for Inadequate Pain Control with IV Paracetamol

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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