What are the doses and dosing schedule for dolutegravir and lamivudine in the first regimen?

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Doses e Posologia do Primeiro Esquema

O primeiro esquema básico consiste em Zidovudina (ZDV) 600 mg por dia divididos em duas ou três doses, combinada com Lamivudina (3TC) 150 mg duas vezes ao dia. 1

Detalhes da Dosagem

  • Zidovudina (ZDV/AZT): 600 mg por dia, administrados em 2 ou 3 doses divididas 1
  • Lamivudina (3TC): 150 mg duas vezes ao dia 1

Formulação Disponível

  • Ambos os medicamentos estão disponíveis como comprimido de dose fixa combinada (COMBIVIR™), que pode ser administrado duas vezes ao dia, simplificando a posologia 1

Contexto Importante

Este esquema foi descrito nas diretrizes de 2001 do CDC para profilaxia pós-exposição ocupacional ao HIV 1. É fundamental notar que este não é mais o esquema de primeira linha recomendado atualmente - as diretrizes mais recentes de 2025 recomendam regimes baseados em inibidores de integrase como dolutegravir combinado com tenofovir/lamivudina ou emtricitabina 1, 2.

References

1
Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

2
Guideline

Antiretroviral Therapy in Adults with HIV

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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