From the FDA Drug Label
The dose may be increased after one week based on clinical response. Lurasidone hydrochloride tablets has been shown to be effective in a dose range of 20 mg per day to 80 mg per day as monotherapy At the end of the clinical study, most of the patients (67%) received 20 mg or 40 mg once daily
The dosage of Latuda should be increased by 20 mg increments, based on clinical response, with a maximum recommended dose of 80 mg per day for pediatric patients and 120 mg per day for adults. 1
From the Research
Latuda (lurasidone) dosage should typically be increased by 20 mg increments. When adjusting Latuda dosage, it's recommended to make changes gradually, usually waiting at least one week between dose increases to allow the medication to reach steady state in your system and to properly assess both therapeutic effects and potential side effects 2. The starting dose for most adults with schizophrenia is 40 mg once daily, which can be increased to a maximum of 160 mg daily if needed. For bipolar depression, the starting dose is typically 20 mg once daily with a maximum of 120 mg daily.
Key Considerations
- Latuda should always be taken with food (at least 350 calories) to ensure proper absorption, as taking it without food can reduce its effectiveness by more than 50% 3.
- Any dosage changes should only be made under the supervision of your healthcare provider, who will consider your specific condition, response to treatment, and any side effects you may be experiencing.
- The effects of dose on exposure to the 3 active metabolites of lurasidone were linear and similar after the administration of single and multiple doses 4.
- Lurasidone doses <120 mg/d were better tolerated compared with higher doses, especially in younger children 4.
- Data from clinical trials of lurasidone in schizophrenia suggest a lower likelihood of weight gain and metabolic problems in patients being treated with lurasidone versus olanzapine and quetiapine 5.