From the Guidelines
Levomepromazine (Methotrimeprazine) acts as an antagonist to dopamine receptors and also has antihistamine, anticholinergic, and antiemetic effects, which contribute to its sedative and analgesic properties [ 1 ].
Mechanism of Action
- The medication's effects are thought to be related to its ability to block dopamine receptors in the brain, which can lead to a range of effects including sedation, antiemesis, and analgesia.
- Additionally, levomepromazine has been shown to have antihistamine properties, which can contribute to its sedative effects [ 1 ].
- The usual dose of a related medication, promethazine, is 12.5 to 25 mg, and its duration of action is 4 to 6 hours [ 1 ].
Clinical Use
- In clinical practice, levomepromazine is often used for its sedative and analgesic effects, and is typically administered in doses of 12.5-25 mg subcutaneously [ 1 ].
- The medication can be used to manage symptoms such as delirium and anxiety, and can be combined with other medications like midazolam for enhanced effect [ 1 ].
From the Research
Mechanism of Action of Levomepromazine (Methotrimeprazine)
There are no research papers provided that directly discuss the mechanism of action of Levomepromazine (Methotrimeprazine) [ 2, 3, 4, 5, 6 ].
Available Information
- The provided studies discuss various topics, including opioid receptor regulation 2, treatment of Alzheimer's disease 3, sensing steroid hormone 17α-hydroxypregnenolone by GPR56 4, celastrol's effect on inflammation in sepsis 5, and cyclical palmitoylation regulating TLR9 signalling 6.
- None of these studies mention Levomepromazine (Methotrimeprazine) or its mechanism of action.
Limitations
- The lack of relevant studies makes it impossible to provide a detailed explanation of the mechanism of action of Levomepromazine (Methotrimeprazine) based on the provided evidence.