What is the cause of edema in the right hand?

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Last updated: April 24, 2025View editorial policy

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Differential Diagnosis for a Puffy Right Hand

  • Single most likely diagnosis
    • Trauma or injury: This is often the most common reason for a puffy hand, as it can lead to swelling due to inflammation or fluid accumulation from damaged tissues.
  • Other Likely diagnoses
    • Infection (cellulitis or abscess): Bacterial infections can cause swelling, redness, and warmth in the affected area.
    • Allergic reaction: An allergic reaction to an insect bite, food, or substance can cause swelling in the hand.
    • Arthritis (rheumatoid or osteoarthritis): Certain types of arthritis can cause swelling and puffiness in the hands, especially in the fingers.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Compartment syndrome: A serious condition that occurs when pressure within the muscles builds to dangerous levels, cutting off blood flow and potentially leading to permanent damage.
    • Deep vein thrombosis (DVT): A blood clot in the deep veins of the arm can cause swelling and requires immediate medical attention to prevent pulmonary embolism.
    • Sepsis: In severe cases of infection, sepsis can occur, which is a life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs.
  • Rare diagnoses
    • Lymphedema: A chronic condition characterized by swelling in one or more extremities, resulting from impaired flow in the lymphatic system.
    • Sarcoidosis: A disease characterized by the growth of tiny collections of inflammatory cells (granulomas) in any part of the body, which can cause swelling in the hands.
    • Angioedema: A rare condition characterized by the rapid swelling of the skin and mucous membranes, which can be life-threatening if not treated promptly.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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