What causes chondromalacia (softening of cartilage)?

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Last updated: April 24, 2025View editorial policy

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From the Guidelines

Chondromalacia is primarily caused by trauma, labral tears, and femoroacetabular impingement (FAI), among other factors, which lead to articular cartilage damage and degeneration. The management of chondral injuries is complex and challenging, especially in weight-bearing joints such as the hip. Several causative factors have been implicated, including:

  • Trauma
  • Labral tears
  • Femoroacetabular impingement (FAI)
  • Arthritis
  • Osteonecrosis
  • Dysplasia As reported by McCarthy and Lee, most chondral injuries in the hip joint were associated with labral tears and were located in the anterior quadrant of the acetabulum (59%) 1. Patients with chondral injuries of the hip typically have a history of hip catching or locking and present with pain in the groin area that occasionally radiates to the buttock or thigh.

The underlying problem of chondral damage is not solved by nonsurgical methods of alleviating pain, which are considered temporizing measures. Hip-preserving strategies are particularly applicable in younger patients (age ≤50 years) to preempt degeneration of the entire joint. Early detection and management of focal chondral injuries are crucial to prevent the progression of the disease. According to the study published in The Journal of the American Academy of Orthopaedic Surgeons, additional research is needed to expand our knowledge of and develop guidelines for management of chondral injuries of the hip 1.

In terms of diagnosis, physical examination should be thorough, focusing on intra-articular and extra-articular causes of pain. Plain radiography can be used to detect joint space narrowing but not focal chondral defects. Advances in hip arthroscopy have broadened the spectrum of tools available for diagnosis and management of chondral damage 1. Surgical options, such as microfracture, articular cartilage repair, autologous chondrocyte implantation, mosaicplasty, and osteochondral allograft transplantation, may be considered in severe cases. However, the literature is still not sufficiently robust to draw firm conclusions regarding best practices for chondral defects 1.

From the Research

Causes of Chondromalacia

  • Chondromalacia patellae (CMP) is caused by several factors, including trauma, increased cartilage vulnerability, patellofemoral instability, bony anatomic variations, abnormal patellar kinematics, and occupation hazards 2
  • The initial pathological changes include cartilage softening, swelling, and edema 2
  • Quadriceps wasting, patellofemoral crepitus, and effusion are obvious clinical indications of CMP 2

Risk Factors

  • Young patients are typically affected by CMP, which is characterized by anterior knee pain (AKP) that is associated with visible changes in patellar cartilage 2
  • Anterior knee pain commonly affects young women, resulting in the declination of the quality of life 3
  • Occupation hazards may also contribute to the development of CMP 2

Pathophysiology

  • Although CMP is used to describe the softening of patellar articular cartilage, it remains a general descriptive term as it cannot be associated with a specific pathophysiologic mechanism 3
  • CMP may be reversible or may progress to develop patellofemoral osteoarthritis 2

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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