From the FDA Drug Label
After addition of buspirone to the diazepam dose regimen, no statistically significant differences in the steady-state pharmacokinetic parameters (Cmax, AUC, and Cmin) of diazepam, but increases of about 15% were seen for nordiazepam, and minor adverse clinical effects (dizziness, headache, and nausea) were observed
- Valium (diazepam) and Buspar (buspirone) can be taken together, but with caution, as there may be an increase in nordiazepam levels and minor adverse clinical effects.
- Key considerations:
- No statistically significant differences in diazepam pharmacokinetic parameters
- 15% increase in nordiazepam levels
- Minor adverse clinical effects (dizziness, headache, and nausea) may occur
- Clinical decision: Monitor patients for adverse effects and adjust dosages as necessary 1
From the Research
Taking Valium (diazepam) and Buspar (buspirone) together should only be done under careful medical supervision as this combination requires caution. These medications can be prescribed together in certain situations, but they affect the brain differently: Valium is a benzodiazepine that enhances GABA effects for immediate anxiety relief, while Buspar works on serotonin receptors with a delayed onset of 2-4 weeks. The combination may increase side effects like drowsiness, dizziness, and impaired coordination.
Key Considerations
- Typically, this combination might be used during transition periods when starting Buspar while gradually tapering off Valium, as Buspar is not habit-forming and better for long-term use 2.
- Dosing must be individualized by your doctor based on your specific condition, medical history, and response to treatment.
- Never adjust doses yourself or stop either medication abruptly, especially Valium, which requires gradual tapering to prevent withdrawal symptoms, as highlighted in a recent study on benzodiazepines 2.
- Always inform your doctor about all medications you're taking, including over-the-counter products and supplements, to avoid potentially dangerous interactions.
Mechanism and Effects
- Valium enhances GABA effects for immediate anxiety relief, while Buspar works on serotonin receptors with a delayed onset of 2-4 weeks 3.
- The combination may increase side effects like drowsiness, dizziness, and impaired coordination, but buspirone has been shown to have a preferable psychomotor side effect profile compared to diazepam 4.
- Buspirone does not impair psychomotor or cognitive function and appears to have no additive effect with alcohol, making it a useful addition to treatments for generalized anxiety 3.