In a patient with a large asymmetrically enlarged right thyroid lobe showing multinodular goiter with substernal/mediastinal extension, mild leftward tracheal shift, an aberrant retro‑esophageal right subclavian artery, and no significant airway narrowing or pathologic lymphadenopathy, what are the appropriate next diagnostic and management steps?

Next Steps for Multinodular Goiter with Substernal Extension and Aberrant Anatomy

Given the substernal extension, mass effect, and aberrant retro-esophageal right subclavian artery (which signals high risk for nonrecurrent laryngeal nerve), this patient requires thyroid function testing, ultrasound-guided fine-needle aspiration of suspicious nodules, and surgical referral to a high-volume thyroid surgeon for definitive management. 1, 2

Immediate Diagnostic Workup

Thyroid Function Assessment

• Measure serum TSH first to determine if the goiter is toxic (hyperfunctioning) or nontoxic, as this fundamentally changes management strategy 2, 3
• If TSH is suppressed, measure free T4 and total T3 to confirm thyrotoxicosis and consider radioiodine uptake scan to differentiate toxic multinodular goiter from other causes 3
• Euthyroid patients proceed directly to nodule evaluation 4

Nodule Risk Stratification and Biopsy

• Perform high-resolution thyroid ultrasound to characterize individual nodules for malignancy risk using ACR TI-RADS or similar criteria 1, 5
• Obtain ultrasound-guided fine-needle aspiration of any nodules meeting size and sonographic criteria for biopsy, as approximately 5% of multinodular goiters harbor malignancy 5, 4
• The presence of multiple nodules does not reduce cancer risk; each suspicious nodule requires individual assessment 5, 4

Critical Anatomic Consideration

Aberrant Vascular Anatomy and Surgical Risk

• The retro-esophageal right subclavian artery identified on imaging strongly predicts the presence of a nonrecurrent right laryngeal nerve (occurs in <1% of cases), which takes an aberrant course directly from the cervical vagus and is at significantly higher risk for injury during thyroidectomy 1
• This anatomic variant mandates preoperative notification to the surgeon and consideration for preoperative laryngoscopy to document baseline vocal fold function 1
• Referral to a high-volume thyroid surgeon (>100 thyroidectomies annually) is essential, as complication rates are 4-fold higher with low-volume surgeons 2

Indications for Surgery

This Patient Meets Multiple Surgical Criteria

• Substernal/mediastinal extension is an indication for surgery because radioactive iodine is less effective for substernal goiters and surgery provides definitive decompression 2, 6, 7
• Mass effect with tracheal deviation, even without significant luminal narrowing currently, warrants surgical intervention before progressive growth causes airway compromise 6, 7, 8
• Large asymmetric goiters should be treated surgically before they develop further substernal extension, as sudden growth can seriously compromise respiration 6

Observation is Not Appropriate

• While asymptomatic nontoxic multinodular goiters with benign cytology may be observed in some cases 9, 4, this patient's substernal extension and mass effect preclude conservative management 2, 6
• Levothyroxine suppression therapy is controversial and ineffective for reducing established multinodular goiter size 9

Preoperative Planning

Additional Imaging Already Complete

• The CT scan already performed has appropriately documented substernal extension and tracheal displacement 1
• CT is superior to ultrasound and MRI for evaluating substernal extension and degree of tracheal compression 1
• No additional cross-sectional imaging is needed unless malignancy is confirmed on FNA 1

Preoperative Laryngoscopy

• Obtain baseline laryngoscopy to document vocal fold mobility before surgery, as detection of vocal fold paralysis doubles when routine preoperative examination is performed 1
• This is particularly important given the aberrant vascular anatomy predicting nonrecurrent laryngeal nerve 1

Common Pitfalls to Avoid

• Do not delay surgery for levothyroxine suppression trials in patients with substernal goiters, as medical therapy is ineffective and delays definitive treatment 2, 9
• Do not assume all nodules are benign simply because multiple nodules are present; FNA of suspicious nodules is mandatory 5, 4
• Do not proceed to surgery without informing the surgeon about the retro-esophageal subclavian artery, as this predicts nonrecurrent laryngeal nerve anatomy 1
• Do not use radioactive iodine as first-line therapy for substernal goiters, as it is less effective than surgery for this indication 2