What is another name for acalabrutinib?

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Last updated: February 23, 2026 • View editorial policy

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Alternative Names for Acalabrutinib

Acalabrutinib is marketed under the brand name Calquence®. 1, 2

Brand and Chemical Names

  • Brand name: Calquence® 1, 2
  • Chemical name: 4-{8-Amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide (2Z)-2-butenedioic acid hydrate 1
  • Salt form: Acalabrutinib maleate 1
  • Development code: ACP-196 3

Active Metabolite

  • Major active metabolite: ACP-5862 (also known as M27), which is a pyrrolidine ring-opened ketone/amide derivative that contributes to the clinical efficacy of acalabrutinib 4
  • ACP-5862 is formed through CYP3A4-mediated metabolism and demonstrates potent and selective covalent BTK inhibition, with only twofold lower potency than the parent compound 4

Drug Classification

  • Pharmacological class: Bruton tyrosine kinase (BTK) inhibitor 1, 3
  • Generation: Second-generation BTK inhibitor, designed to be more selective and potent than the first-generation agent ibrutinib 3

References

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