From the FDA Drug Label
Store your new, unused OZEMPIC pens in the refrigerator between 36°F to 46°F (2°C to 8°C). Store your pen in use for 56 days at room temperature between 59°F to 86°F (15°C to 30°C) or in a refrigerator between 36°F to 46°F (2°C to 8°C)
Yes, OZEMPIC needs to be refrigerated before use, specifically new, unused pens. However, once in use, it can be stored at room temperature or in the refrigerator for up to 56 days 1.
From the Research
Yes, Ozempic (semaglutide) needs to be refrigerated before first use. The medication should be stored in a refrigerator at 36°F to 46°F (2°C to 8°C) until you're ready to start using it. Once you begin using an Ozempic pen, you can store it at room temperature (below 86°F or 30°C) for up to 56 days (8 weeks). After this period, any unused medication should be discarded even if there is solution left in the pen. Refrigeration is necessary before first use because semaglutide is a protein-based medication that can degrade if exposed to higher temperatures for extended periods. The cold temperature helps maintain the stability and effectiveness of the medication. When storing Ozempic, keep the pen cap on to protect it from light and always ensure the needle is removed after each injection. Never freeze Ozempic as this can damage the medication and render it ineffective.
Some key points to consider when storing Ozempic include:
- Storing the medication in the refrigerator before first use to maintain its stability and effectiveness 2
- Keeping the pen cap on to protect it from light when not in use
- Ensuring the needle is removed after each injection to prevent contamination and damage to the pen
- Discarding any unused medication after 56 days (8 weeks) of storage at room temperature
- Avoiding freezing the medication, as this can cause damage and render it ineffective
It's also important to note that the storage and handling of Ozempic are crucial to its effectiveness and safety. By following the recommended storage and handling procedures, you can help ensure that the medication remains stable and effective, and that you get the best possible results from your treatment. Unfortunately, none of the provided studies 3, 4, 5, 6 discuss the storage requirements of Ozempic, but based on general knowledge of protein-based medications, refrigeration before first use is necessary to maintain the stability and effectiveness of the medication.