From the Research
Group C streptococcal throat infections should be treated with penicillin V (phenoxymethylpenicillin) 500 mg orally twice daily for 10 days, as this regimen is effective in reducing symptom duration, preventing spread, and minimizing potential complications, similar to the treatment approach for Group A strep 1.
Key Considerations
- The treatment approach for Group C strep is similar to that of Group A strep, with a focus on reducing morbidity, mortality, and improving quality of life.
- Penicillin V is the recommended first-line treatment, with alternatives available for patients with penicillin allergy, such as azithromycin or clindamycin.
- Supportive care, including adequate hydration, rest, and over-the-counter pain relievers, is also important in managing symptoms.
Evidence-Based Recommendations
- A study published in the American Family Physician found that penicillin is the treatment of choice for streptococcal pharyngitis due to its cost, narrow spectrum of activity, and effectiveness 1.
- Another study published in the Archives of Pediatrics & Adolescent Medicine found that cefpodoxime is also effective in treating group A beta-hemolytic streptococcal tonsillopharyngitis, but penicillin V remains the first-line treatment 2.
- A study on the comparative susceptibility of clinical group A, B, C, F, and G beta-hemolytic streptococcal isolates to 24 antimicrobial drugs found that group C streptococci are susceptible to penicillin G, ampicillin, and other beta-lactam antibiotics, as well as clindamycin, chloramphenicol, and vancomycin 3.
Clinical Implications
- The recommended treatment regimen for Group C strep should be based on the most recent and highest-quality evidence available.
- Clinicians should consider the potential for penicillin allergy and have alternative treatment options available.
- Supportive care and patient education are essential in managing symptoms and preventing complications.