Retatrutide Concentration After Dilution
When you dilute 20 mg of retatrutide in 3 mL of normal saline, the resulting concentration is 6.67 mg/mL.
Calculation Method
To determine the concentration in mg per mL, divide the total amount of drug by the total volume:
- 20 mg ÷ 3 mL = 6.67 mg/mL 1
This is a straightforward dilution calculation where the mass of the active pharmaceutical ingredient (retatrutide) is distributed evenly throughout the diluent volume (normal saline).
Clinical Context for Retatrutide
While the provided evidence focuses primarily on epinephrine and norepinephrine dilution protocols, the mathematical principle for calculating drug concentrations remains identical across all medications 1.
- Retatrutide is administered as a once-weekly subcutaneous injection for obesity and type 2 diabetes, with maintenance doses ranging from 0.5 mg to 12 mg 2, 3
- In clinical trials, retatrutide demonstrated dose-dependent weight reduction and glycemic control improvements over 48 weeks 2, 3
- The medication is typically supplied in pre-filled injection devices rather than requiring manual dilution for clinical use 2
Important Considerations
- Verify the accuracy of your initial retatrutide amount (20 mg) and final volume (3 mL) before administration
- Ensure proper sterile technique when performing any medication dilution
- Label the diluted solution clearly with the final concentration (6.67 mg/mL), date, time, and your initials
- Store according to manufacturer specifications for retatrutide stability