From the Guidelines
Vibrio is a type of bacteria that causes cholera, and the recommended treatment is doxycycline, with alternative options including ciprofloxacin, azithromycin, or ceftriaxone, as stated in the 2017 Infectious Diseases Society of America clinical practice guidelines 1.
Key Points
- The treatment of Vibrio cholerae infection typically involves aggressive rehydration as primary therapy, with antibiotics serving as adjunctive therapy 1.
- The choice of antibiotic should be guided by susceptibility patterns, with doxycycline being the preferred option 1.
- Alternative antibiotics for Vibrio cholerae infection include ciprofloxacin, azithromycin, and ceftriaxone, which can be used if doxycycline is not suitable or available 1.
Important Considerations
- The treatment of Vibrio cholerae infection should be individualized based on the patient's clinical presentation, medical history, and susceptibility patterns 1.
- It is essential to note that antibiotic resistance is a growing concern, and the choice of antibiotic should be guided by local resistance patterns and susceptibility testing, if available 1.
- The 2017 Infectious Diseases Society of America clinical practice guidelines provide a comprehensive overview of the diagnosis and management of infectious diarrhea, including Vibrio cholerae infection, and should be consulted for further guidance 1.
From the Research
Definition of Viibryd
- Viibryd, also known as vilazodone, is a dual-acting antidepressant that combines the properties of a selective serotonin reuptake inhibitor (SSRI) and a serotonin 5-HT1A receptor partial agonist 2, 3, 4, 5, 6.
- It is approved in the US for the treatment of major depressive disorder (MDD) in adults 2, 3, 4, 5, 6.
Mechanism of Action
- Vilazodone works by blocking the serotonin reuptake transporter and acting as a 5-HT1A receptor partial agonist, which contributes to its antidepressant effects 2, 3, 4, 5, 6.
- The combination of these two mechanisms of action is unique to vilazodone and may offer advantages in terms of efficacy and tolerability 2, 3, 4, 5, 6.
Efficacy and Safety
- Vilazodone has been shown to be effective in reducing symptoms of depression in adults with MDD, as demonstrated in several clinical trials 2, 3, 4, 5, 6.
- The most common side effects of vilazodone include diarrhea, nausea, and headache, which are generally mild to moderate in severity 2, 3, 4, 5, 6.
- Vilazodone has a relatively benign tolerability profile, with minimal effects on sexual function and body weight 2, 3, 4, 5, 6.