From the FDA Drug Label
DIRECTIONS: Adults 1 to 2 teaspoons one to two times daily. Children under twelve one half adult dosage. Consult a physician for use in children under 12 years of age. The FDA drug label does not answer the question.
From the Research
Ademetionine should typically be taken for 2-12 weeks, depending on the condition being treated, with a maximum duration guided by the patient's response and medical supervision 1. The standard treatment duration can vary significantly based on the condition being treated. For depression, a course of 4-6 weeks is common, while liver conditions may require 8-12 weeks of treatment.
- The dosage ranges from 200-3200 mg daily, often divided into multiple doses, as seen in various studies 2, 3, 4, 1.
- It's essential to follow a doctor's specific instructions regarding duration, as they will tailor recommendations based on the medical condition, response to treatment, and potential side effects.
- Some patients with chronic conditions like depression or liver disease may require longer-term maintenance therapy under medical supervision.
- Ademetionine works by supporting methylation processes in the body, helping to produce and regulate hormones, neurotransmitters, and maintain cell membranes.
- If considering stopping ademetionine, it's crucial to consult a healthcare provider first rather than discontinuing abruptly, especially if it's been taken for depression. The most recent and highest quality study, published in 2024, provides an updated systematic review and meta-analysis on the use of S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression, guiding the recommendation for its use 1.