Major Nerve Bundle Tracts in the Spinal Cord
Overview
The spinal cord contains distinct ascending (sensory) and descending (motor) white matter tracts that are organized peripherally around a central gray matter core, with each tract serving specific sensory or motor functions. 1
Descending (Motor) Tracts
Corticospinal Tract
- The corticospinal tract is the primary descending motor pathway, carrying upper motor neuron information from the motor cortex to lower motor neurons in the spinal cord. 1
- This tract controls voluntary movement and is located in the lateral and anterior white matter columns. 2, 3
- Damage to the corticospinal tract produces ipsilateral motor deficits (weakness on the same side as the lesion). 1
- The corticospinal tract has direct cortico-motoneuronal connections that are particularly important for adaptive motor behaviors involving distal extremities (hands and feet). 2
Other Descending Motor Tracts
- The rubrospinal tract originates from the red nucleus and assists with motor control. 3
- The vestibulospinal tracts (medial and lateral) originate from vestibular nuclei and control balance and posture. 3
- The reticulospinal tracts (rostral and caudal) originate from the reticular formation and modulate motor activity and autonomic functions. 3
Ascending (Sensory) Tracts
Dorsal Column-Medial Lemniscus Pathway
- The gracile and cuneate fasciculi form the dorsal columns and carry fine touch, vibration, and proprioception information. 1, 3
- The gracile fasciculus (medial) carries information from the lower body and legs. 3
- The cuneate fasciculus (lateral) carries information from the upper body and arms. 3
- These tracts ascend ipsilaterally, meaning damage produces sensory loss on the same side as the lesion. 1
Spinothalamic Tracts (Anterolateral System)
- The spinothalamic tracts carry pain and temperature sensations from the periphery to the brain. 1, 4, 5
- The lateral spinothalamic tract primarily conveys pain and temperature. 1, 3
- The anterior spinothalamic tract carries crude touch and pressure. 3
- These pathways are crossed, meaning they decussate (cross over) in the spinal cord, so damage produces sensory loss on the contralateral (opposite) side of the body. 1
- The spinothalamic tract projects to the lateral parabrachial nucleus and thalamus, conveying both nociceptive and affective touch information. 5
Spinocerebellar Tracts
- The dorsal and ventral spinocerebellar tracts carry proprioceptive information from muscles and joints to the cerebellum for motor coordination. 3
- These tracts are essential for unconscious proprioception and motor planning. 3
Postsynaptic Dorsal Column Pathway
- The postsynaptic dorsal column pathway carries visceral and some cutaneous sensory information. 3
Gray Matter Organization
Laminar Structure
- The central gray matter is organized into laminae (layers) numbered 1-10. 1
- Laminae 1-5 (posterior/dorsal horn) process sensory information, including pain, temperature, and touch. 1
- Lamina 9 (anterior/ventral horn) contains lower motor neurons that directly innervate skeletal muscles. 1
- The intermediate gray matter contains autonomic neurons and interneurons. 1
Clinical Correlation: Spinal Cord Injury Patterns
Brown-Séquard Syndrome (Hemisection)
- Unilateral corticospinal tract damage causes ipsilateral motor weakness. 1
- Unilateral dorsal column damage causes ipsilateral loss of fine touch and vibration. 1
- Unilateral spinothalamic tract damage causes contralateral loss of pain and temperature sensation. 1, 4
Central Cord Syndrome
- Damage to commissural fibers (crossing pain/temperature fibers) produces a suspended bilateral "girdle" sensory level with loss of pain and temperature at the level of injury but preservation above and below. 1
Autonomic Dysfunction
- Bilateral cord involvement affecting autonomic pathways in the lateral columns produces autonomic dysfunction, including bladder, bowel, and cardiovascular abnormalities. 1, 4
Important Clinical Pitfalls
- The spinothalamic tract crosses within 1-2 spinal segments of entry, so the sensory level for pain/temperature is typically 1-2 segments below the actual lesion. 4
- Dorsal column pathways do not cross until the medulla, so they remain ipsilateral throughout the spinal cord. 1
- Cordotomy complications (surgical interruption of the spinothalamic tract) have revealed that the anterolateral system also contains descending reticular pathways controlling respiration (Ondine's curse), micturition, and autonomic functions. 4