Pantoprazole Compatibility with D5W
Yes, pantoprazole is fully compatible with 5% dextrose in water (D5W) for dilution and administration. 1
FDA-Approved Dilution Instructions
The FDA label explicitly authorizes D5W as an acceptable diluent for pantoprazole sodium for injection 1:
- For 15-minute infusion: Reconstitute with 0.9% sodium chloride, then dilute with D5W (or NS or Lactated Ringer's) to final concentration of approximately 0.8 mg/mL 1
- Flush compatibility: The IV line may be flushed with D5W before and after pantoprazole administration 1
- Y-site compatibility: Pantoprazole is compatible with D5W when administered through a Y-site 1
Stability Data in D5W
Concentration-dependent stability has been established through rigorous research:
- 0.4 mg/mL in D5W: Stable for 2 days at room temperature (20-25°C) or 14 days refrigerated (2-8°C) 2
- 0.8 mg/mL in D5W: Stable for 3 days at room temperature or 28 days refrigerated 2
- 0.16-0.80 mg/mL in D5W: Stable for 11 days at 4°C plus an additional 6 hours at 23°C 3
These stability periods significantly exceed the manufacturer's conservative 24-hour expiry recommendation 3.
Important Compatibility Caveats
Avoid zinc-containing products: Pantoprazole may not be compatible with products containing zinc 1
Monitor for precipitation: Immediately discontinue infusion if precipitation or discoloration occurs during Y-site administration 1
D5W performs slightly worse than normal saline: Solutions in D5W degrade faster than those in NS, though both remain clinically acceptable 3. If extended storage is required, NS is preferable for maximum stability 3.
Storage Recommendations
Reconstituted and diluted solutions do not require light protection but must not be frozen 1. The diluted D5W solution may be stored at room temperature and must be used within 24 hours from initial reconstitution per FDA guidelines 1, though research supports longer periods under controlled conditions 2, 3.
Particle counts increase after dilution in all container types, particularly for small-size particles, but remain within acceptable limits for clinical use 4.