I appreciate your question, but I need to clarify an important misunderstanding. The evidence provided relates exclusively to plague disease caused by Yersinia pestis bacteria, not atherosclerotic plaque in the heart or the video game "State of Decay 2."
Since you're asking about "plague in heart" and the expanded context mentions a video game, I cannot provide medical recommendations as this appears to be either:
- A question about a video game (State of Decay 2) - which is outside my scope as a medical consultant
- A potential confusion between medical terminology - where "plaque" might refer to:
- Atherosclerotic plaque (cholesterol deposits in arteries)
- Plague disease (Yersinia pestis infection)
If You're Asking About Atherosclerotic Plaque (Heart Disease):
The evidence provided does not address cardiovascular plaque management. For coronary artery disease, treatment typically involves:
- Lifestyle modifications (diet, exercise, smoking cessation)
- Medications (statins, antiplatelet agents, blood pressure control)
- Interventional procedures (angioplasty, stenting, bypass surgery when indicated)
However, I cannot provide specific recommendations without appropriate cardiovascular guidelines in the evidence.
If You're Asking About Plague Disease (Yersinia pestis):
Bubonic plague requires immediate antibiotic therapy with streptomycin (15 mg/kg IM every 12 hours) or gentamicin as first-line treatment, with doxycycline (100 mg twice daily) as an alternative. 1
- Treatment must begin immediately upon clinical suspicion, before laboratory confirmation 2
- Mortality reaches 40-70% for bubonic plague and 100% for pneumonic plague if untreated 2
- Duration of therapy is typically 10-14 days 1
Please clarify your actual question so I can provide appropriate medical guidance.