From the Research
Ethinylestradiol/cyproterone acetate is an effective treatment for menstrual regulation, particularly in women with polycystic ovary syndrome, hirsutism, or acne, as evidenced by the most recent and highest quality study 1. The standard regimen involves taking one pill daily for 21 consecutive days, followed by a 7-day break during which withdrawal bleeding occurs, simulating a normal menstrual cycle. Each tablet typically contains 35 mcg of ethinylestradiol and 2 mg of cyproterone acetate. For best results, take the pill at approximately the same time each day. Start on the first day of your menstrual period or on the first Sunday after your period begins. If you miss a pill, take it as soon as you remember, even if it means taking two pills in one day. If you miss two or more pills, use backup contraception for 7 days. This medication works by suppressing ovulation, thinning the endometrial lining, and thickening cervical mucus. Some key benefits of this treatment include:
- Reduction in hyperandrogenic skin symptoms, such as acne and hirsutism, as shown in a study published in 2017 1
- Regulation of menstrual irregularities
- Decreased risk of endometrial cancer
- Potential preservation of fertility However, it's essential to weigh these benefits against the risk of venous thromboembolic complications, as noted in the study 1. Side effects may include nausea, breast tenderness, headaches, and mood changes, which typically improve after 2-3 months of use. Be aware that this medication increases the risk of blood clots, so it's contraindicated in women with certain risk factors like smoking, hypertension, or previous thromboembolism, as discussed in the study 2. In terms of endothelial function, a pilot study published in 2011 found that ethinylestradiol/cyproterone acetate improved endothelial function in young, non-obese women with polycystic ovary syndrome 3. Overall, ethinylestradiol/cyproterone acetate is a valuable treatment option for menstrual regulation, particularly in women with polycystic ovary syndrome, hirsutism, or acne, when used under the guidance of a healthcare provider and with careful consideration of the potential risks and benefits.