Sugammadex (Bridion) Vial Strengths and Concentrations
Sugammadex is supplied as 200 mg/2 mL (100 mg/mL) and 500 mg/5 mL (100 mg/mL) single-dose vials for intravenous bolus injection. 1
Available Formulations
- 200 mg/2 mL vial: Contains 100 mg/mL concentration in a single-dose vial 1
- 500 mg/5 mL vial: Contains 100 mg/mL concentration in a single-dose vial 1
- Both formulations are sterile, clear, colorless to slightly yellow-brown, non-pyrogenic aqueous solutions intended for intravenous infusion 1
Clinical Dosing Context
The vial sizes are designed to accommodate the weight-based dosing requirements for reversal of neuromuscular blockade:
- Moderate blockade: 2 mg/kg typically requires 140-200 mg for a 70-100 kg adult 2
- Deep blockade: 4 mg/kg typically requires 280-400 mg for a 70-100 kg adult 2
- Very deep blockade: 8 mg/kg may require 560-800 mg for a 70-100 kg adult 2
Cost-Saving Considerations in Pediatric Practice
- In pediatric patients, vial-splitting into 50 mg and 100 mg aliquots under sterile pharmacy conditions can significantly reduce waste and cost, as most pediatric patients receive ≤50 mg doses due to weight-based dosing 3
- Using quantitative neuromuscular monitoring to guide dosing can produce net cost savings of approximately $46 per case by preventing unnecessary administration when spontaneous recovery is adequate 4