What amount of metformin is contained in Synjardy (empagliflozin/metformin) tablets?

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Last updated: February 24, 2026 • View editorial policy

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Synjardy Metformin Content

Synjardy (empagliflozin/metformin) is available in six fixed-dose combination strengths containing either 500 mg, 850 mg, or 1,000 mg of metformin paired with either 5 mg or 12.5 mg of empagliflozin. 1

Available Dose Combinations

The specific formulations of Synjardy include:

  • Empagliflozin 5 mg / Metformin 500 mg 1, 2
  • Empagliflozin 5 mg / Metformin 850 mg 1
  • Empagliflozin 5 mg / Metformin 1,000 mg 1, 2
  • Empagliflozin 12.5 mg / Metformin 500 mg 1, 2
  • Empagliflozin 12.5 mg / Metformin 850 mg 1
  • Empagliflozin 12.5 mg / Metformin 1,000 mg 1, 2

Dosing Considerations

The maximum approved daily dose of metformin in Synjardy is 2,000 mg, typically administered as two tablets taken twice daily. 2 For example, patients may receive empagliflozin 12.5 mg/metformin 1,000 mg twice daily, providing a total daily metformin dose of 2,000 mg and empagliflozin dose of 25 mg. 2

Bioequivalence

The fixed-dose combination tablets have been demonstrated to be bioequivalent to the individual component tablets taken together at all tested dose strengths under both fed and fasted conditions. 1, 3 This means the metformin content in Synjardy is absorbed identically to standalone metformin tablets at equivalent doses.

References

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