Drotin (Drotaverine) Tablet Composition
Drotin tablets contain drotaverine hydrochloride as the active pharmaceutical ingredient, typically available in 40 mg and 80 mg strengths.
Active Ingredient
- Drotaverine hydrochloride is the sole active pharmaceutical ingredient in Drotin tablets 1, 2
- The drug is an antispasmodic agent structurally related to papaverine 1
Common Formulation Strengths
- 40 mg tablets: Standard adult dose formulation
- 80 mg tablets: Higher strength formulation, often used in fixed-dose combinations 3
- 30 mg tablets: Pediatric formulation for children aged 6-12 years 2
Pharmaceutical Characteristics
- Drotaverine hydrochloride is formulated as the hydrochloride salt to enhance stability and bioavailability 4
- The compound acts primarily as a spasmolytic agent through smooth muscle relaxation 3
- Modern formulations may include superdisintegrants (such as soy polysaccharides) to create orodispersible tablets with disintegration times under 180 seconds 2
Fixed-Dose Combination Products
- Drotaverine 80 mg + Paracetamol 500 mg: This combination is available for enhanced pain relief in conditions like acute infectious gastroenteritis, demonstrating superior efficacy compared to paracetamol alone 3
- Compatibility studies confirm drotaverine can be safely combined with NSAIDs like ibuprofen and ketoprofen without adverse drug-drug interactions 5
Excipients (Typical)
While specific excipient composition varies by manufacturer, modern formulations commonly include: