From the FDA Drug Label
The activity of oxycodone hydrochloride tablets is primarily due to the parent drug oxycodone. Oxycodone hydrochloride tablets are designed to provide immediate release of oxycodone Table 2: Pharmacokinetic Parameters (Mean±SD) ... Tmax (hr) ... Single Dose Pharmacokinetics ... 1.8±1.8 ... 1.4±0.7 ... 1.9±1.5 ... 2.6±3.0 Food-Effect, Single Dose ... Tmax (hr) ... 1.25±0.5 ... 2.54±1.2
The onset of action of oxycodone (Immediate Release) is approximately 1 to 3 hours after administration, as indicated by the time to maximum concentration (Tmax) values ranging from 1.25 to 2.6 hours in the pharmacokinetic studies 1.
From the Research
Onset of Action of Oxycodone (Immediate Release)
- The onset of action of oxycodone immediate release is approximately 30-60 minutes after administration 2.
- A study found that the median time to onset of relief was 41 minutes for immediate-release oxycodone 2.
- Another study mentioned that the effect of oxycodone commences one hour after administration, but this is for the controlled-release formulation, and it is not explicitly stated for the immediate-release formulation 3.
- However, it can be inferred that the onset of action for the immediate-release formulation would be faster than the controlled-release formulation, given the differences in their formulations and release mechanisms 3, 2.
Comparison with Other Formulations
- The onset of action of immediate-release oxycodone is faster compared to controlled-release oxycodone, which has a duration of action of 10 to 12 hours 2.
- Immediate-release oxycodone has a shorter duration of action, approximately 7 hours, compared to controlled-release oxycodone 2.
- The pharmacokinetics of oxycodone, including its onset of action, can be influenced by factors such as the rate of drug release and absorption, which can vary between different formulations 4.