Haff Disease: Clinical Overview and Management
What is Haff Disease?
Haff disease is an acute rhabdomyolysis syndrome caused by consumption of certain fish or shellfish contaminated with an unidentified toxin, characterized by sudden onset of severe muscle pain, weakness, and markedly elevated creatine kinase levels, typically occurring within 24 hours of ingestion.
Based on the evidence provided, there is no guideline or research literature specifically addressing "Hoof's disease" or "Haff disease" in the medical context. The evidence documents focus exclusively on:
- Animal hoof disorders in equines (horses, donkeys, ponies) 1, 2, 3, 4
- Zoonotic infections from animal contact 5, 6
- Parasitic infections from animals 5, 7, 8
- Contagious ovine digital dermatitis in sheep 9
- Fibrodysplasia ossificans progressiva (FOP), an unrelated human genetic disorder 5
Clinical Clarification Required
If you are asking about Haff disease (the human rhabdomyolysis syndrome), no specific guidelines were provided in the evidence. This condition requires:
- Immediate recognition of the classic triad: recent fish/shellfish consumption, severe myalgias, and CK elevation >1000 U/L
- Aggressive IV hydration to prevent acute kidney injury from myoglobinuria
- Monitoring of renal function, electrolytes (particularly potassium and calcium), and urine output
- Supportive care as the condition is self-limiting in most cases
If you are asking about animal hoof diseases, the evidence indicates:
- Hoof disorders affect 85% of horses, with thrush (45%), superficial hoof wall cracks (30.4%), and sole bruises (24.7%) being most common 2
- Management includes regular hoof trimming, appropriate bedding (straw preferred over flax for some conditions), maintaining dry stable floors, and addressing poor horn quality 2
- Contagious ovine digital dermatitis in sheep requires parenteral long-acting amoxicillin as efficacious treatment 9
Please clarify whether you are asking about the human disease (Haff disease/rhabdomyolysis) or animal hoof conditions, as the provided evidence does not contain guidelines for human "Hoof's disease" or "Haff disease."