From the FDA Drug Label
2.2 Juvenile Idiopathic Arthritis or Pediatric Uveitis The recommended subcutaneous dosage of HUMIRA for patients 2 years of age and older with polyarticular juvenile idiopathic arthritis (JIA) or pediatric uveitis is based on weight as shown below. Pediatric Weight (2 Years of Age and older)Recommended Dosage 10 kg (22 lbs) to less than 15 kg (33 lbs)10 mg every other week 15 kg (33 lbs) to less than 30 kg (66 lbs)20 mg every other week 30 kg (66 lbs) and greater40 mg every other week
The recommended dose of Humira for a pediatric patient weighing 48.10 kg to treat JIA is 40 mg every other week 1.
From the Research
For a pediatric patient weighing 48.10 kg with juvenile idiopathic arthritis (JIA), the recommended Humira (adalimumab) dose is 40 mg every other week, administered as a subcutaneous injection. This dosing is based on the patient's weight, as they are above 30 kg, and is supported by the study published in 2014 2. The medication should be stored in the refrigerator (36-46°F/2-8°C) and protected from light. Before administration, allow the prefilled syringe or pen to reach room temperature for 15-30 minutes. Injection sites include the thigh or abdomen (at least 2 inches from the navel), rotating sites with each injection. Some key points to consider when administering Humira to pediatric patients with JIA include:
- Common side effects, such as injection site reactions, upper respiratory infections, and headache, should be monitored 3
- Parents should be aware of the signs of infection, as Humira suppresses the immune system by blocking tumor necrosis factor (TNF), a key inflammatory protein involved in JIA pathogenesis 4
- Regular follow-up appointments are essential to assess treatment response and monitor for potential adverse effects, including the development of anti-adalimumab antibodies, which can be associated with loss of response 5
- The use of concomitant methotrexate may be considered, as it has been shown to be effective in combination with adalimumab in treating JIA, although the importance of combination therapy is still unclear 6.