From the Research
Buscopan (hyoscine butylbromide) is generally considered safe for people with Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency. Unlike certain medications that can trigger hemolytic anemia in G6PD-deficient individuals, Buscopan works as an antispasmodic that affects smooth muscle in the gastrointestinal tract without interacting with red blood cell metabolism. The medication functions by blocking muscarinic receptors, reducing spasms in the digestive system, and relieving symptoms like abdominal pain and cramping.
Key Points to Consider
- The typical adult dose is 10-20 mg taken up to four times daily, with a maximum daily dose of 100 mg.
- Side effects may include dry mouth, constipation, blurred vision, and increased heart rate.
- Patients should inform their healthcare provider about all medications they're taking, as Buscopan may interact with certain drugs like antidepressants, antihistamines, and other medications with anticholinergic properties.
- While generally safe in G6PD deficiency, individuals should still consult their healthcare provider before starting any medication, especially if they have other medical conditions such as glaucoma, enlarged prostate, or heart problems.
- According to a review of medications and G6PD deficiency 1, there is no evidence to contravene the use of Buscopan in normal therapeutic doses to G6PD-deficient patients.
Evidence-Based Recommendation
Based on the most recent and highest quality study available, Buscopan can be safely used in patients with G6PD deficiency 1. It is essential to note that while Buscopan is considered safe, patients with G6PD deficiency should always consult their healthcare provider before starting any new medication, especially if they have other underlying medical conditions. Additionally, patients should be aware of the potential interactions between Buscopan and other medications they are taking, as reported in various studies 2, 3, 4, 5.