Retatrutide Concentration Calculation
When 20 mg of retatrutide is diluted in 350 mL of normal saline, the final concentration is approximately 0.057 mg/mL.
Calculation Method
The concentration is determined by dividing the total drug amount by the total volume:
- Total retatrutide: 20 mg
- Total volume: 350 mL
- Concentration: 20 mg ÷ 350 mL = 0.057 mg/mL (or approximately 0.06 mg/mL when rounded)
Clinical Context
While the provided evidence focuses on retatrutide's clinical efficacy for obesity and type 2 diabetes rather than dilution calculations, the pharmacokinetic studies demonstrate that retatrutide is administered subcutaneously in doses ranging from 0.5 mg to 12 mg weekly 1, 2. The dilution you're describing (20 mg in 350 mL) would be unusual for standard subcutaneous administration and may represent a preparation for a different route or research protocol.
Important Considerations
- Verify the intended route: Retatrutide in clinical trials has been administered subcutaneously at much smaller volumes 1, 2, 3
- Stability concerns: Like other peptide medications, retatrutide's stability after dilution should be confirmed, as many compounds become unstable after reconstitution 4, 5
- Aseptic technique: If preparing this dilution, maintain strict sterile technique throughout the process 5
The mathematical answer remains 0.057 mg/mL, but clinical application should be verified against the specific protocol or prescribing information for your intended use.