From the Guidelines
Average Doses of Medications for Endotracheal Intubation (ETI)
The average doses of medications for ETI typically include 1.5-2.5 mg/kg of propofol administered over 30-60 seconds, 0.1-0.2 mg/kg of midazolam given 1-2 minutes prior to intubation, and 0.5-1.0 mg/kg of rocuronium or 1.0-1.5 mg/kg of succinylcholine administered to facilitate muscle relaxation 1.
Medication Details
- Propofol: administered over 30-60 seconds, with a duration of action lasting 3-10 minutes 1.
- Midazolam: given 1-2 minutes prior to intubation, with a duration of action lasting 30-60 minutes 1.
- Rocuronium: used at a dose above 0.9 mg/kg, with a duration of action lasting 30-60 minutes 1.
- Succinylcholine: has a shorter duration of action, lasting 4-6 minutes, and is used at a dose of 1.0-1.5 mg/kg 1.
- Fentanyl: may be administered at a dose of 1-2 mcg/kg, 2-3 minutes prior to intubation, to provide analgesia 1.
Key Considerations
- The choice of medication and dosage may vary depending on the patient's medical history, age, and clinical situation 1.
- Muscle relaxants, such as succinylcholine and rocuronium, are recommended to improve intubation conditions and limit adverse events 1.
- Sugammadex may be used to reverse the effects of rocuronium, but its use should be balanced against the risk of anaphylaxis 1.
From the FDA Drug Label
The average dose required to produce neuromuscular blockade and to facilitate tracheal intubation is 0.6 mg/kg Succinylcholine Chloride Injection given intravenously. Intubation using doses of rocuronium bromide 0.6 to 0.85 mg/kg was evaluated in 203 adults in 11 clinical studies.
The average doses of medications to administer for endotracheal intubation (ETI) are: