From the Guidelines
Suboxone is not recommended for methamphetamine withdrawal. Suboxone, which contains buprenorphine and naloxone, is specifically designed to treat opioid dependence by binding to opioid receptors in the brain. Methamphetamine, however, primarily affects dopamine and norepinephrine systems rather than opioid receptors, making Suboxone ineffective for managing methamphetamine withdrawal symptoms. According to the World Health Organization guidelines 1, management of withdrawal from amphetamines, which includes methamphetamine, is best undertaken in a supportive environment, and no specific medication is recommended for the treatment of their withdrawal. Some key points to consider in the management of methamphetamine withdrawal include:
- Relief of symptoms, such as agitation or sleep disturbance, may be achieved with symptomatic medication for the period of the withdrawal syndrome 1.
- Less commonly, depression or psychosis can occur during withdrawal, and in these cases, the individual needs to be monitored closely and advice sought from relevant specialists, if available 1.
- The most effective approaches for methamphetamine addiction include behavioral therapies like cognitive-behavioral therapy (CBT), contingency management, and participation in support groups. While research continues to explore potential medications for methamphetamine addiction, current evidence does not support using Suboxone for this purpose.
From the Research
Methamphetamine Withdrawal Treatment
- There is no established medication for methamphetamine withdrawal, and current treatments are primarily focused on managing symptoms and cravings 2, 3.
- Some studies have investigated the use of various medications, including bupropion, buprenorphine, and others, but the evidence is limited and inconclusive 2, 3, 4, 5.
Buprenorphine for Methamphetamine Withdrawal
- One study found that buprenorphine was effective in reducing methamphetamine cravings, and its administration was associated with a significant reduction in craving scores 4.
- Buprenorphine, also known as Suboxone when combined with naloxone, is commonly used for opioid withdrawal treatment, and its use for methamphetamine withdrawal is being explored 6.